Clinical Research Site Director - 249262

Medix™; Mesquite (TX); On-site; USD 130,000 - 220,000; Full time

Benefits offered by this job

Competitive compensation structure

Long-term leadership opportunities

Job summary

A growing clinical research organization in Mesquite, TX, is seeking a Clinical Research Site Director to lead operations and drive performance at a high-performing site. The ideal candidate will have over 7 years of clinical research experience, strong operational leadership skills, and a solid understanding of budgets and sponsor negotiations. This role will involve overseeing clinical trials, managing staff, and identifying business development opportunities, while playing a critical part in the organization's strategic growth and expansion initiatives.

Qualifications

• 7+ years of clinical research experience with progressive operational leadership.
• Prior experience as a Site Director, Senior Clinical Research Manager, or equivalent.
• Strong understanding of study budgets, contracts, and sponsor negotiations.
• Experience running multiple concurrent trials.

Responsibilities

• Provide full operational oversight of all clinical trials at the site.
• Lead, mentor, and manage cross-functional research staff.
• Oversee study start-up through close-out, ensuring compliance and performance excellence.
• Manage study budgets, contract negotiations, and financial forecasting.
• Conduct and lead feasibility assessments (FQs).
• Serve as the primary liaison to sponsors and CROs.
• Identify and cultivate business development opportunities.
• Implement operational efficiencies and scalable processes.
• Partner with ownership on strategic growth initiatives, including future satellite expansion.

Skills

Operational Leadership

Budget Management

Sponsor Negotiation

Team Leadership

Entrepreneurial Mindset

Job description

Job title: Clinical Research Site Director

Location: Mesquite, TX (Relocation candidates will be considered; Texas-based candidates preferred)

A growing, physician-led clinical research site in the Dallas–Fort Worth area is conducting a confidential search for an experienced Clinical Research Site Director to lead operations at a high-performing, single-site research organization.

This is a pivotal leadership opportunity for a seasoned research professional who is ready to step into a true operational leadership role — partnering directly with the Principal Investigator (PI) to drive site performance, sponsor relationships, and long-term expansion strategy.

About the Opportunity

The site is led by an experienced and well-respected Principal Investigator who currently serves as the primary PI across multiple active trials. With a strong internal team already in place — including 12 CRCs, regulatory staff, laboratory personnel, and administrative support — the organization is seeking a strategic operational leader who can elevate execution, streamline processes, and serve as the external-facing representative to sponsors and CROs.

The current structure includes an acting site manager; however, this role is designed to establish a more strategic Head of Operations who can fully oversee study conduct, financial oversight, and business development initiatives, allowing the PI to focus on patient care and scientific leadership.

This is a family-operated organization with strong values, long-term vision, and plans for future satellite site expansion.

Key Responsibilities

• Provide full operational oversight of all clinical trials at the site
• Lead, mentor, and manage cross-functional research staff (CRCs, regulatory, lab, front office)
• Oversee study start-up through close-out, ensuring compliance and performance excellence
• Manage study budgets, contract negotiations, and financial forecasting
• Conduct and lead feasibility assessments (FQs)
• Serve as the primary liaison to sponsors and CROs
• Identify and cultivate business development opportunities
• Implement operational efficiencies and scalable processes
• Partner with ownership on strategic growth initiatives, including future satellite expansion

Ideal Candidate Profile

• 7+ years of clinical research experience with progressive operational leadership
• Prior experience as a Site Director, Senior Clinical Research Manager, or equivalent
• Strong understanding of study budgets, contracts, and sponsor negotiations
• Experience running multiple concurrent trials
• Demonstrated ability to lead and scale teams
• Strong sponsor-facing presence and communication skills
• Entrepreneurial mindset with interest in long-term growth
• Willingness to relocate to the Dallas–Fort Worth area (if not local)

Candidates who bring both hands‑on study leadership experience and a strategic mindset will thrive in this environment.

Why This Role?

• Direct partnership with an experienced, respected PI
• Established infrastructure and strong study pipeline
• Opportunity to build and formalize operational leadership
• Strategic input into site expansion and growth
• Competitive compensation structure
• Long‑term leadership track within a growing organization