Chief of Staff

Broaden; San Francisco (CA); On-site; USD 72,000 - 120,000; Full time

Benefits offered by this job

Equity

Job summary

Broaden, a San Francisco-based AI & Frontier Enzyme Design startup, seeks a Chief of Staff to act as the core operational engine across the business. In-person, full-time, you will coordinate ML, biology, and lab workflows, driving zero-to-one initiatives and ensuring execution against ambitious goals.

Reporting to the CEO, you will remove bottlenecks, structure cross-team execution, and manage external partnerships while scaling workflows to accelerate breakthroughs into organizational

Qualifications

• Proven ability to translate complex goals into concrete plans and drive them to completion.
• Excellent written and verbal communication across technical and non-technical teams.
• Strong sense of initiative, detail-orientation, and problem-solving.
• Experience coordinating cross-functional activities in fast-paced environments.

Responsibilities

• Partner with founders to establish internal operating systems and track deliverables.
• Bridge communication and timelines between ML, biology, and lab operations.
• Own high-priority initiatives from definition to measurable outcomes.
• Support investor relations and external partner communications with clear updates.
• Manage day-to-day operations, facilities, procurement, and tooling to maintain focus on execution.

Skills

Cross-functional collaboration

Operational leadership

Project management

Strategic planning

Communication

Job description

Chief of Staff | AI & Frontier Enzyme Design Startup | San Francisco,CA (In-Person) | Full-Time | Up to $120K + Equity

About The Company

Our client builds next-generation tooling to manipulate chemistry and biology, starting with programmable enzyme design. They operate on the conviction that as AI scales, scientific progress will be bottlenecked by the specialised interfaces that allow agents to explore and understand the physical world.

By treating enzymes as the programmable machinery of biology and coupling generative structural modelling with rapid experimental feedback loops, they are building computational systems that deliberately search enzyme space to design new biological catalysts and interventions on a weekly basis.

They are a lean, interdisciplinary team of researchers and builders spanning biology, chemistry, mathematics, and computer science, united by the belief that scientific discovery is approaching a major step change.

About The Role

Reporting directly to the CEO, the Chief of Staff will serve as the core operational engine across the business. Working across an interdisciplinary team bridging machine learning, structural biology, and wet-lab operations, you will own the operational cadence and execute critical zero-to-one initiatives that translate technical breakthroughs into organisational momentum.

This is a high-leverage role for an autonomous generalist operator who thrives in fast-moving, high-conviction environments. You will remove operational bottlenecks, structure team-wide execution, lead cross-functional strategic projects, and maintain the operational rigour required to design and test new biological systems continuously.

Key Responsibilities

• Partner with the founders to establish internal operating systems, track cross-team deliverables, resolve bottlenecks, and ensure company-wide alignment.
• Bridge communication, workflows, and timelines between computational modelling, data engineering, and wet-lab experimental feedback loops.
• Own and incubate high-priority initiatives that do not yet have an organisational home - including hiring workflows, external partnerships, vendor operations, and operational scaling.
• Support investor relations, external partner communications, and the preparation of high-signal presentations, research updates, and board materials.
• Manage day-to-day corporate operations, facilities, procurement, and team tooling to ensure a lean research team maintains uninterrupted focus on technical execution.

Skills & Competencies

• Proven ability to synthesise complex, ambiguous challenges into concrete plans and drive them to completion with minimal direction.
• Strong intellectual curiosity and comfort engaging with technical concepts across biological systems, machine learning, and computational science.
• Clear, structured written and verbal communication, capable of distilling complex research ideas into concise operational priorities and executive summaries.
• A proactive builder mindset that seeks out friction, streamlines processes, and executes with high attention to detail.
• Strong judgment in managing competing priorities, high-stakes external relationships, and sensitive company information.

Qualifications & Experience

• Prior experience in early-stage tech/deeptech operations, management consulting, venture capital, Investment Banking, or a similar fast-paced analytical environment.
• Demonstrated track record of independently leading cross-functional projects from problem definition to measurable outcome.
• Professional exposure to, or strong academic interest in, biotechnology, AI/ML, computational science, or engineering disciplines.
• Experience working directly alongside founders or executive leadership to scale workflows and infrastructure.

Details

• Full-time role in San Francisco, CA.
• Up to $120K + Equity.
• Opportunity to join a small team and scale a business.