Chemistry Scientist (Large Molecule / Drug Substance)

Ampcus Inc; Spring House (PA); On-site; USD 80,000 - 86,000; Full time

Job summary

Ampcus Inc. is seeking a Chemistry Scientist 2 for large-molecule/drug substance purification in Spring House, PA, onsite. Role focuses on process development, purification strategies, and hands-on experimentation to support biologics processes.

Responsibilities include interpreting analytical data, training colleagues, and contributing to DOE efforts with emphasis on scalable models and PAT approaches. Strong documentation and collaboration in a cross-functional team are essential.

Qualifications

• Bachelor’s, Master’s, or Ph.D. in Chemistry or related discipline with industry experience.
• Hands-on LC systems experience (Protein A, CEX, AEX).
• Experience with biologics purification and SP-TFF / UF/DF.
• Strong documentation and notebook skills.

Responsibilities

• Design and perform process development experiments for biologics purification.
• Execute studies on LC, SP-TFF, UF/DF and filtration operations.
• Apply reduced-scale models and support PAT approaches.
• Prepare solutions, sample handling, data submission, and documentation.
• Interpret analytical data to inform purification strategies and decisions.
• Contribute to DOE and protein/large-molecule purification innovation.
• Write memos and present data internally.
• Train and mentor others on techniques and equipment.

Skills

Protein A chromatography

SP-TFF / UF/DF

Data interpretation

Lab documentation

Education

Bachelor’s degree in Chemistry or related

Master’s degree in Chemistry/biotech

Tools

KTA Pure

KTA Avant

Job description

Chemistry Scientist 2 Large Molecule / Drug Substance Scientist

Duration: 09/21/2026 12/31/2026 (possibility of extension)

Location: Spring House, PA (100% onsite)

Pay Rate: $39.71/hr

Role Overview

We are seeking a Chemistry Scientist 2 to support Manufacturing Science and Technology (MSAT) process development activities focused on large-molecule / drug substance purification for biologics (including antibodies).

The successful candidate will design, execute, and analyze laboratory-scale experiments to support upstream and downstream purification development of biologic drug substances. Responsibilities include process characterization studies involving liquid chromatography, concentration/filtration operations, and related unit operations. The role emphasizes the application of scaled-down models representative of commercial processes, data interpretation to guide process decisions, and contribution to process instructions and process validation readiness.

Approximately 90% of the work is hands-on experimental. The candidate will prepare solutions, handle samples, execute workflows, collect/record/interpret data, present findings internally, write technical documents, and help train/mentor colleagues on techniques and equipment. The individual will also stay current with scientific advances and help introduce relevant new concepts or technologies into the workflow. Collaboration in a cross-functional team environment is expected.

Key Responsibilities

• Design and perform process development and characterization experiments supporting novel biologics purification.
• Execute studies on liquid chromatography, solution concentration (e.g., SP-TFF, UF/DF), and filtration operations.
• Apply reduced-scale models and support Process Analytical Technology (PAT) approaches.
• Prepare solutions, perform sample handling/submission, and maintain accurate documentation/notebooks.
• Interpret analytical data to inform purification strategies and process decisions.
• Contribute to Designs of Experiments (DOE) and innovation efforts related to protein/large-molecule purification and analysis.
• Write technical memos and present data at internal meetings.
• Train and mentor others on relevant techniques and equipment as needed.

Required Qualifications

• Bachelor s, Master s, or Ph.D. in Chemistry, Chemical Engineering, Biotechnology, or a related scientific discipline, with relevant industry experience (typically 4+ years with BS, 2+ years with MS, or 1+ year with Ph.D.).
• Hands-on experience with liquid chromatography systems (e.g., Protein A, CEX, AEX) experience on systems such as KTA Pure or KTA Avant strongly preferred.
• Experience with large-molecule / biologics drug substance manufacturing processes (antibodies preferred).
• Knowledge and practical experience with biologics solution concentration techniques (SP-TFF and UF/DF).
• Experience with filtration operations and sample submission workflows.
• Strong documentation and laboratory notebook skills.

Preferred Qualifications

• Experience with protein purification and characterization using common analytical methods (e.g., A280, SEC, Raman, NIR, ProG, etc.).
• Experience with filter sizing (depth, sterile, nano filtration) and resin lifetime studies.
• Familiarity with GMP processes.
• Strong technical writing, oral presentation, and cross-functional teamwork skills.

Top Non-negotiable Skills

• Hands-on experience with downstream biotherapeutic manufacturing operations, particularly Protein A chromatography.
• Proven experience with biologics solution concentration (SP-TFF / UF/DF) and filtration.
• Strong laboratory documentation / notebook skills and ability to work independently in a process-development setting.

This is a fully onsite laboratory role focused on practical process development support for large-molecule drug substance. Candidates must be authorized to work in the location and available for the full assignment duration.

Ampcus is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, age, protected veterans, or individuals with disabilities.

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