Cell Therapy Bioanalytical Strategy Lead

Roche; South San Francisco (CA); On-site; USD 173,000 - 322,000; Full time

Benefits offered by this job

Relocation benefits available

Job summary

Genentech is seeking a Senior Principal Scientist to lead the Bioanalytical Strategy for our Cell Therapy programs. You will define integrated data strategies, partner across disciplines, and set best practices to accelerate development and informed portfolio decisions.

You will collaborate with Regulatory, Clinical Development, and Computational Sciences to translate complex bioanalytical data into actionable insights, mentor teams, and help shape the future of cell therapy modalities.

Qualifications

• Ph.D. in Immunology, Cell Biology, Biochemistry, Pharmacology, Bioanalytical Sciences, or related field with 7+ years in drug discovery or development.
• Direct experience supporting cell therapy development (CAR-T, TCR-T, TILs, iPSC-derived products).
• Deep understanding of cell therapy bioanalytical challenges and translating data into insights for development decisions.
• Strong knowledge of flow cytometry, qPCR/ddPCR, ligand-binding assays, functional bioassays, biomarker assays, and multi-omic approaches.
• Ability to influence scientific strategy and lead cross-functional initiatives without direct authority.
• Recognized scientific leadership with publications, patents, or regulatory contributions and excellent communication skills.

Responsibilities

• Define and drive the bioanalytical strategy for the Cell Therapy portfolio, creating integrated, fit-for-purpose data strategies.
• Identify and evolve key questions to characterize in vivo fate of therapeutic cells (expansion, persistence, trafficking, biodistribution, immunogenicity).
• Partner with Bioanalytical Sciences project leads to develop integrated strategies across development.
• Build strategic partnerships across Research, Translational Medicine, Development Sciences, Clinical, CMC, Regulatory, Computational Sciences, and platform organizations.
• Harmonize scientific approaches, share assays and data, and establish portfolio-wide best practices.
• Drive consistency and excellence by standardizing approaches and enabling cross-program data interpretation.
• Integrate bioanalytical, translational, clinical, computational, and manufacturing insights to support progression and regulatory planning.
• Translate emerging questions into clear evidence-generation strategies and data interpretation across programs.
• Evaluate emerging advances and guide incorporation of innovative bioanalytical approaches.
• Represent Bioanalytical Sciences on governance teams and collaborations; mentor scientists across matrixed organizations.

Skills

Bioanalytical strategy

Cross-functional leadership

Scientific communication

Data integration

Regulatory collaboration

Education

Ph.D. in Immunology/biological sciences

Tools

Flow cytometry

qPCR/ddPCR

Ligand-binding assays

Functional biomarker assays

Biomarker assays

Multiomics

Job description

Genentech is seeking a Senior Principal Scientist to lead the Bioanalytical Strategy for our Cell Therapy programs. You will define integrated data strategies, partner across disciplines, and set best practices to accelerate development and informed portfolio decisions.

You will collaborate with Regulatory, Clinical Development, and Computational Sciences to translate complex bioanalytical data into actionable insights, mentor teams, and help shape the future of cell therapy modalities.