Cell Biologist & Assay Developer — Early-Stage Biotech

Flagship Pioneering Co-Op Program

Boston (MA)

On-site

USD 100,000 - 127,000

Full time

14 days+

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Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Abiologics, Inc. is seeking a highly motivated cell biologist and assay developer to join our Pharmacology team.

You will develop and execute biochemical and cell-based assays supporting the pipeline, with potential in vivo/ex vivo work and cross-functional collaboration to advance platform growth. Qualifications include a PhD in molecular or cell biology (or related) with industry experience preferred, expertise in mammalian cell culture, and proficiency in multiple assay platforms.

Qualifications

PhD in molecular or cell biology or related discipline; up to 2 years relevant experience; industry experience preferred
Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; imaging/analysis experience a plus (Incucyte, Phenix)
Experienced with primary cell culture and characterization, including tissue dissociation
Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays and interpret complex results
Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
In vivo pharmacology experience would be a plus
Proficiency in laboratory automation and semi-automated screening workflows is a plus
Industry level experience with best practices related to data records creation and maintenance and workflow integrity
Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

Responsibilities

Design and execute cell-based and biochemical assays to assess Syntein activity, target engagement, and mechanism of action to drive discovery programs
Conceptualize and develop novel assays for diverse target classes and disease areas with guidance from manager
Collaborate with Pharmacology on biochemistry and biophysics projects and provide cell biology expertise
Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for screening funnels
Ensure rapid generation and accurate reporting of high-quality data; collaborate with Computational Design and Chemistry & Screening teams
Communicate scientific findings to a diverse team at project team meetings