Scientist I, In Vitro Pharmacology

Flagship Pioneering Co-Op Program; Boston (MA); On-site; USD 100,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Abiologics, Inc. is seeking a highly motivated cell biologist and assay developer to join our Pharmacology team.

You will develop and execute biochemical and cell-based assays supporting the pipeline, with potential in vivo/ex vivo work and cross-functional collaboration to advance platform growth. Qualifications include a PhD in molecular or cell biology (or related) with industry experience preferred, expertise in mammalian cell culture, and proficiency in multiple assay platforms.

Qualifications

• PhD in molecular or cell biology or related discipline; up to 2 years relevant experience; industry experience preferred
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
• Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; imaging/analysis experience a plus (Incucyte, Phenix)
• Experienced with primary cell culture and characterization, including tissue dissociation
• Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays and interpret complex results
• Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
• In vivo pharmacology experience would be a plus
• Proficiency in laboratory automation and semi-automated screening workflows is a plus
• Industry level experience with best practices related to data records creation and maintenance and workflow integrity
• Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

Responsibilities

• Design and execute cell-based and biochemical assays to assess Syntein activity, target engagement, and mechanism of action to drive discovery programs
• Conceptualize and develop novel assays for diverse target classes and disease areas with guidance from manager
• Collaborate with Pharmacology on biochemistry and biophysics projects and provide cell biology expertise
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
• Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for screening funnels
• Ensure rapid generation and accurate reporting of high-quality data; collaborate with Computational Design and Chemistry & Screening teams
• Communicate scientific findings to a diverse team at project team meetings

Skills

Mammalian cell culture

Transfection & lentiviral transduction

Cell-based assays

Flow cytometry

Bioanalytical techniques

Imaging & analysis

Independent assay development

Data interpretation

Team collaboration

Education

PhD in molecular or cell biology

Industry experience

Tools

Incucyte

Phenix

Laboratory automation

Job description

COMPANY DESCRIPTION

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins™ , a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology.

Abiologics was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

THE ROLE

We are looking for a highly motivated, broadly skilled cell biologist and assay developer to join our growing Pharmacology team. In this role, the successful candidate will be responsible for developing and executing biochemical and cell-based assays to support the progression of Abiologics’ pipeline. Occasionally, this individual may contribute to in vivo and ex-vivo pharmacology activities to progress projects and the platform. In addition, this role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company growth.

KEY RESPONSIBILITIES

• Design and execute cell-based and biochemical assays to assess SynteinTM activity, target engagement, and mechanism of action to drive discovery programs
• With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas
• Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
• Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross-training of colleagues on methods
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design-make-test cycles
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

• PhD in molecular or cell biology or related discipline with up to 2 years relevant experience; industry experience is preferred
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
• Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
• Experienced with primary cell culture and characterization, including tissue dissociation
• Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
• Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
• Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
• In vivo pharmacology experience would be a plus
• Proficiency in laboratory automation and semi-automated screening workflows is a plus
• Industry level experience with best practices related to data records creation and maintenance and workflow integrity
• Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

The salary range for this role is $100,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Abiologics, Inc’s good faith estimate as of the date of publication and may be modified in the future.

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