Scientist I, In Vitro Pharmacology

Abiologics; Boston (MA); On-site; USD 100,000 - 126,500; Full time

Benefits offered by this job

Health care coverage

Annual incentive program

Retirement benefits

Job summary

Abiologics, Inc. in Boston is seeking a motivated cell biologist and assay developer to join their Pharmacology team. The successful candidate will design and execute assays to assess Syntein activity and support their growing pipeline.

Requirements include a PhD in molecular or cell biology, technical expertise in cell culture, and strong assay development skills. Benefits include healthcare and a competitive salary range of $100,000 – $126,500.

Qualifications

• Up to 2 years of relevant experience, preferably in industry.
• Proficient in bioanalytical techniques and industry-standard assays.
• Strong background in renal disease biology is highly desirable.

Responsibilities

• Design and execute cell-based assays to assess Syntein activity.
• Collaborate with the Pharmacology team on related projects.
• Ensure accurate reporting of high-quality data.

Skills

Mammalian cell culture

Assay development

Flow cytometry

Biochemical assays

Team collaboration

Education

PhD in molecular or cell biology

Tools

TR-FRET

Lumit

ELISA

Western blot

Incucyte

Job description

Abiologics, Inc. is a privately held, early‑stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies.

Role Overview

We are looking for a highly motivated, broadly skilled cell biologist and assay developer to join our growing Pharmacology team. In this role, the successful candidate will be responsible for developing and executing biochemical and cell‑based assays to support the progression of Abiologics’ pipeline. Occasionally, this individual may contribute to in vivo and ex‑vivo pharmacology activities to progress projects and the platform. The role will collaborate cross‑functionally with a diverse design‑make‑test team across Abiologics and have the opportunity to impact platform and company growth.

Key Responsibilities

• Design and execute cell‑based and biochemical assays to assess Syntein activity, target engagement, and mechanism of action to drive discovery programs.
• With guidance from the manager, conceptualize and develop novel assays for diverse target classes and disease areas.
• Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise.
• Contribute to in vivo and ex‑vivo pharmacology activities to progress projects and the platform.
• Collaborate cross‑functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross‑training of colleagues on methods.
• Ensure rapid generation and accurate reporting of high‑quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design‑make‑test cycles.
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings.

Professional Experience & Qualifications

• PhD in molecular or cell biology or a related discipline with up to 2 years relevant experience; industry experience is preferred.
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines.
• Proficient in industry‑standard cell‑based assays and bioanalytical techniques including TR‑FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high‑content imaging and image analysis a plus (e.g., Incucyte, Phenix).
• Experienced with primary cell culture and characterization, including tissue dissociation.
• Experienced in assay development and testing in model systems and humans with good understanding of analytical and pre‑analytical methods and solutions.
• Demonstrated ability to independently design, develop and optimize diverse cell‑based functional assays (e.g., intracellular signaling) and interpret complex results.
• Strong proficiency in renal disease biology and preclinical kidney models is highly desirable.
• In vivo pharmacology experience would be a plus.
• Proficiency in laboratory automation and semi‑automated screening workflows is a plus.
• Industry‑level experience with best practices related to data records creation and maintenance and workflow integrity.
• Demonstrated ability to work in a fast‑paced environment; self‑driven, creative, with a strong team‑oriented mentality.

Equal Opportunity Employer

We are an equal‑opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

The salary range for this role is $100,000 – $126,500. Abiologics, Inc. currently offers health care coverage, an annual incentive program, retirement benefits, and a broad range of other benefits. Compensation and benefits information are based on Abiologics’ good‑faith estimate as of the date of publication and may be modified in the future.