In Vitro Pharmacology Scientist: Cell Assay Innovator

Abiologics; Watertown (MA); Vor Ort; USD 100.000 - 127.000; Vollzeit

Zusammenfassung

Abiologics, Inc. is a privately held biotechnology company focused on Synteins, a novel class of macromolecular medicines.

We seek a skilled cell biologist and assay developer to develop biochemical and cell-based assays supporting our pipeline, with potential in vivo/ex vivo contributions and cross-functional collaboration across Abiologics. The role demands experimental design, execution of diverse assays, and rapid data reporting to advance discovery programs and platform growth within a

Qualifikationen

• PhD in molecular or cell biology or related discipline with up to 2 years relevant experience; industry experience is preferred
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
• Proficient in industry‑standard cell‑based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
• Experienced with primary cell culture and characterization, including tissue dissociation
• Experienced in assay development and testing in model systems and human with good understanding of analytical and pre‑analytical methods and solutions
• Demonstrated ability to independently design, develop and optimize diverse cell‑based functional assays (e.g., intracellular signaling) and interpret complex results
• Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
• In vivo pharmacology experience would be a plus
• Proficiency in laboratory automation and semi‑automated screening workflows is a plus
• Industry level experience with best practices related to data records creation and maintenance and workflow integrity
• Demonstrated ability to work in a fast‑paced environment; self‑driven, creative, with a strong team‑oriented mentality

Aufgaben

• Design and execute cell-based and biochemical assays to assess Syntein TM activity, target engagement, and mechanism of action to drive discovery programs
• With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas
• Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
• Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross‑training of colleagues on methods
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design‑make‑test cycles
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings

Kenntnisse

Cell culture

Transfection

Lentiviral transduction

Reporter cell lines

Assay development

TR-FRET

Lumit

ELISA

Western blot

Flow cytometry

In vivo pharmacology

Ausbildung

PhD in molecular or cell biology

Tools

Incucyte

Phenix

Jobbeschreibung

Abiologics, Inc. is a privately held biotechnology company focused on Synteins, a novel class of macromolecular medicines.

We seek a skilled cell biologist and assay developer to develop biochemical and cell-based assays supporting our pipeline, with potential in vivo/ex vivo contributions and cross-functional collaboration across Abiologics. The role demands experimental design, execution of diverse assays, and rapid data reporting to advance discovery programs and platform growth within a