Cardiac Metabolism Research Lead

University of California - Los Angeles (UCLA); Los Angeles (CA); Vor Ort; USD 79.000 - 92.000; Vollzeit

Zusammenfassung

The Deb Laboratory in the Division of Cardiology, Department of Medicine at UCLA seeks an Assistant Project Scientist to lead research on the methionine salvage pathway (MSP) and its metabolite in cardiovascular disease. This is an independent, research-intensive role within a well-funded program supported by NIH grants.

The successful candidate will design and lead projects, work with genetically engineered mouse models, perform advanced metabolomics and single-cell sequencing, and contribute

Qualifikationen

• Ph.D. or equivalent required.
• Direct research experience with cardiac metabolism.
• Experience with mouse models and echocardiographic/hemodynamic phenotyping.
• Proficiency in standard molecular and biochemical techniques.
• Expertise in single-cell/single-nucleus multiome analysis and epigenomic profiling.
• Experience with stem cell, iPSC or organoid culture systems.
• Publications in high-impact journals in cardiovascular research, metabolism or cell biology.

Aufgaben

• Design, lead and execute research projects on MSP regulation of cardiac metabolism and epigenome in cardiovascular disease.
• Utilize and develop mouse models, including conditional knockouts, for disease studies.
• Perform in vivo/in vitro isotope tracing, metabolomics and energetics analyses.
• Generate and analyze single-cell multi-omics and metabolomics datasets.
• Establish human iPSC-derived cardiomyocytes and organoids for validation studies.
• Prepare manuscripts, figures and progress reports; contribute to grants.

Kenntnisse

Cardiac metabolism

Mouse models

Molecular techniques

Single-cell multiomics

iPSC/organoid culture

Grant writing

Ausbildung

Ph.D. or equivalent

Jobbeschreibung

The Deb Laboratory in the Division of Cardiology, Department of Medicine at UCLA seeks an Assistant Project Scientist to lead research on the methionine salvage pathway (MSP) and its metabolite in cardiovascular disease. This is an independent, research-intensive role within a well-funded program supported by NIH grants.

The successful candidate will design and lead projects, work with genetically engineered mouse models, perform advanced metabolomics and single-cell sequencing, and contribute