Bioprocess Operator: Hands-On Pilot-Scale Fermentation

Dakota BioWorx; Brookings (SD); On-site; USD 52,000 - 78,000; Full time

Job summary

Dakota BioWorx is seeking a Bioprocess Operator to execute hands-on bioprocessing at laboratory and pilot scales, including precision fermentation and downstream steps. You will work with bioprocess engineering and operations staff, run equipment safely per SOPs, and help with maintenance and cleaning of facilities.

You will monitor reactors and downstream gear, prepare media and reagents, perform sampling, and keep detailed batch records while collaborating with multi-disciplinary teams to

Qualifications

• Hands-on experience with bioprocess R&D or pilot-scale equipment and unit operations.
• Ability to follow SOPs and maintain batch records.
• Strong mechanical aptitude and troubleshooting skills.
• Excellent communication skills across diverse audiences.

Responsibilities

• Operate and monitor bioreactors, centrifuges, filtration systems, and other production equipment.
• Prepare media, buffers, and reagents for fermentation and downstream processes.
• Perform in-process sampling and analysis.
• Maintain accurate batch records, logbooks, and production documentation.
• Assist with cleaning (CIP/SIP) and sterilization of equipment and production areas.
• Coordinate vendor service calls and equipment calibrations.
• Maintain organization and cleanliness of shop areas, utility rooms, and storage spaces.
• Conduct basic fabrication, assembly, and modification of lab and production fixtures.

Skills

Bioprocess R&D

SOP compliance

Mechanical aptitude

Effective communication

Team collaboration

Tools

Bioreactor operation

CIP/SIP

LOTO procedures

Equipment maintenance

Job description

Dakota BioWorx is seeking a Bioprocess Operator to execute hands-on bioprocessing at laboratory and pilot scales, including precision fermentation and downstream steps. You will work with bioprocess engineering and operations staff, run equipment safely per SOPs, and help with maintenance and cleaning of facilities.

You will monitor reactors and downstream gear, prepare media and reagents, perform sampling, and keep detailed batch records while collaborating with multi-disciplinary teams to