Senior Fermentation Engineer: Scale-Up & Process Optimization

BioPhase Inc.; San Diego (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

BioPhase Inc. is seeking an experienced Bioprocess Engineer to independently design, execute and analyze fermentation experiments aimed at improving titer, rate and yield.

You will develop end-to-end processes from media development to feeding strategies and control, and script automated DoE campaigns to optimize production. The role spans scale-up and tech transfer from bench to pilot and commercial scales, collaborating with strain engineering, analytics, and manufacturing teams to ensure

Qualifications

• B.S./M.S. in Bioprocess Eng, Chemical Eng, Biotechnology, Microbiology or related field with 5+ years of industrial fermentation experience.
• Hands-on fermentation across bacteria, yeasts and/or filamentous fungi in batch, fed-batch and continuous modes.
• Experience installing fermentation equipment and building out qualification documentation.
• Experience scripting bioreactor control — recipes, feed schemes and automated events.
• Strong understanding of mass transfer, mixing, and process economics.
• Experience designing and executing laboratory experiments predictive of large-scale processes.

Responsibilities

• Independently design, execute and analyze bioreactor experiments to improve titer, rate and yield.
• Develop fermentation processes end to end including media development, inoculum train, feeding strategy and process control.
• Script and automate bioreactor operation and DoE campaigns.
• Lead scale-up and tech transfer from bench to pilot and commercial scale.
• Collaborate with strain engineering, downstream processing, analytics, manufacturing and product development teams.
• Establish lab operating backbone with SOPs, batch records, calibration and maintenance.

Skills

Fermentation process development

Scale-up to pilot/commerceal scale

Data analysis & modeling

Mass and energy balances

Process control & automation

Cross-functional collaboration

Education

B.S./M.S. in Bioprocess Eng/ Chem Eng / Biotechnology / Microbiology

Tools

Sartorius

Eppendorf

Applikon

Infors

TJX

Ambr

Caladan

Python

MATLAB

JMP

SuperPro Designer

Aspen

Job description

BioPhase Inc. is seeking an experienced Bioprocess Engineer to independently design, execute and analyze fermentation experiments aimed at improving titer, rate and yield.

You will develop end-to-end processes from media development to feeding strategies and control, and script automated DoE campaigns to optimize production. The role spans scale-up and tech transfer from bench to pilot and commercial scales, collaborating with strain engineering, analytics, and manufacturing teams to ensure