Biomarker Strategy Lead, Translational Medicine

Marrow Therapeutics; Watertown (MA); On-site; USD 200,000 - 280,000; Full time

Job summary

Marrow Therapeutics seeks a Principal Scientist, Biomarkers, to lead biomarker strategy across programs. You will connect discovery to translational medicine and clinical development, shaping biomarker plans and interpreting results with cross-functional teams.

You will work with internal and external labs to implement assays, drive decisions, and ensure sample quality. This role emphasizes scientific rigor and impactful patient outcomes.

Qualifications

• PhD in biology, immunology, pharmacology, biomedical sciences, or a related discipline.
• 6+ years of relevant biotechnology or pharmaceutical industry experience in biomarker science.
• Experience developing and implementing biomarker plans that inform development decisions.
• Strong understanding of disease biology and biomarker applications across studies.
• Experience with human samples and assay-related data quality considerations.
• Scientific expertise in relevant assay technologies and biomarker endpoints.

Responsibilities

• Develop and execute plans to assess target engagement, pharmacodynamic activity, and markers of response.
• Collaborate to evaluate candidate biomarkers and their biological relevance in samples.
• Define hypotheses, approaches, and interpretation criteria for disease biology insights.
• Work with labs to develop and implement biomarker assays suitable for development stage.
• Collaborate on biomarker endpoints, sampling schedules, and lab requirements.
• Contribute to CRO selection, timelines, and data quality improvement.
• Coordinate sample handling to preserve integrity for analysis.
• Translate biomarker data into development recommendations with PK/SA data context.
• Communicate priorities, risks, and resource needs; align with milestones.
• Prepare scientific reports and contribute to regulatory documents and publications.

Skills

Biomarker strategy

Translational medicine

Laboratory expertise

Data integration

Cross-functional leadership

Regulatory documentation

Education

PhD in biology or related

Tools

Flow cytometry

Immunoassays

PCR-based methods

Tissue imaging

Sequencing

Job description

Marrow Therapeutics seeks a Principal Scientist, Biomarkers, to lead biomarker strategy across programs. You will connect discovery to translational medicine and clinical development, shaping biomarker plans and interpreting results with cross-functional teams.

You will work with internal and external labs to implement assays, drive decisions, and ensure sample quality. This role emphasizes scientific rigor and impactful patient outcomes.