Biologist

Spectraforce Technologies; Worcester (MA); On-site; USD 70,000 - 100,000; Full time

Job summary

Spectraforce Technologies is seeking a Biologist for a 6-month, onsite position in Worcester, MA. The role focuses on immunology discovery with human organoid biology, ex vivo tissue processing, and cell-based in vitro assays across a fast-paced, multidisciplinary team.

The ideal candidate will have 4+ years in industry, hands-on primary cell culture, 3D organoid models, and experience with ELISA/MSD/Luminex, qPCR and flow cytometry.

Qualifications

• BS in Biological Sciences with 4+ years in industry.
• In vitro cell culture experience with sterile techniques.
• Experience with primary human organoids.
• Comfortable handling ex vivo human tissue and processing.
• Experience with 3D cell culture models (Transwells or MPS/CIVM).
• Proficiency in ELISA, MSD or Luminex.
• Ability to learn quickly in a fast-paced environment.
• Excellent communication and collaboration skills.
• Able to work independently and in a team.
• Strong problem-solving and attention to detail.

Responsibilities

• Culture and plate human intestinal organoids to support research objectives.
• Perform assays in primary 3D cell culture models such as Transwells or MPS/CIVM platforms.
• Test biologics and small molecules in cell-based assays for proliferation, cytokine release, and gene expression.
• Execute molecular and cellular techniques including flow cytometry, ELISA, MSD, and qPCR.
• Process human tissue ex vivo and isolate organoids, fibroblasts, and immune cells.
• Design, execute, and interpret experiments; communicate results to stakeholders.
• Collaborate with cross-functional teams to address organoid cell needs.
• Develop and optimize new experimental protocols and techniques.
• Document data clearly and rigorously; contribute to multiple projects.
• Drive project impact through hands-on lab work.

Skills

Organoid culture

Primary cell culture

3D cell culture

Immunoassays

Molecular biology

Data analysis

Independent work

Team collaboration

Communication

Education

Bachelor's degree in Biological Sciences

Tools

qPCR

ELISA

MSD

Luminex

FACS (Flow Cytometry)

Transwell

MPS/CIVM

Job description

Job Title: Biologist

Length of Contract: 6 months

Location/Site: ABC - Worcester Massachusetts - 100% onsite; 01604

Interview Process

30 minute Teams meeting - 1 interview

Required Skills, Experience or Education

• Human organoid culture and co‑culture models such as transwells
• Handling human tissues and processing
• BS degree in cell or molecular biology
• Experience with molecular and cellular analysis techniques including qPCR, MSD, ELISA, flow cytometry
• 4+ years experience in industry

Job Description

We are seeking a highly motivated and skilled scientist to join our Immunology Discovery team in Worcester, MA. In this role, you will collaborate with multiple cross‑functional teams to advance portfolio projects, with a core focus on human intestinal organoid biology, ex vivo tissue processing, and cell‑based in‑vitro assay execution. Responsibilities span the full experimental cycle from assay design and execution to data analysis and cross‑team communication across diverse and technically demanding cell systems.

This position offers a unique opportunity to work at the interface of basic research and early drug discovery in a fast‑paced, multidisciplinary environment. The ideal candidate brings hands‑on expertise in primary cell culture, 3D cell models, immunoassays, and molecular biology techniques, and thrives both independently and within a collaborative team setting.

Key Responsibilities

• Culture, passage, and plate human intestinal organoids to support the group's research objectives.
• Perform assays in primary 3D cell culture models such as Transwells or MPS/CIVM platforms.
• Test biologic and small molecule compounds in cell‑based assays for functional readouts, including cell proliferation, cytokine release, and gene expression.
• Execute advanced molecular and cellular biology techniques, including but not limited to flow cytometry (FACS), ELISA, MSD, and qPCR.
• Process human tissue ex vivo and isolate organoids, fibroblasts, and immune cells from human tissue or blood.
• Work independently on the design, execution, and interpretation of experimental results to validate project‑relevant hypotheses.
• Maintain close communication with multiple teams to support human intestinal organoid cell needs.
• Implement and innovate new experimental protocols and techniques as needed.
• Analyze, interpret, document, and report data consistently, concisely, and rigorously, both to individual stakeholders and in group settings.
• Demonstrate scientific excellence through dedicated contributions to multiple projects in a fast‑paced, multidisciplinary environment.
• Drive project impact primarily through hands‑on, lab‑based activities.

Qualifications and Requirements

• Required skills
  • Bachelor's degree in Biological Sciences or a related field, with 4+ years of experience in an industry setting.
  • In vitro cell culture experience, including sterile techniques and handling of challenging cell types.
  • Experience working with primary human organoids.
  • Comfortable handling with ex vivo human tissue and processing.
  • Experience with 3D cell culture models such as transwells or MPS/CIVM platforms.
  • Proficiency in ELISA, MSD or Luminex.
  • Ability to learn new skills and apply them in a fast‑paced research environment.
  • Excellent oral and written communication skills with a collaborative mindset.
  • Comfortable managing, shifting timelines and evolving work priorities.
  • Ability to work both independently and as part of a team.
  • Strong creativity, problem‑solving skills, and attention to detail.
• Skills that are a plus
  • Experience with cell‑based assay development.
  • Proficiency in multi‑color flow cytometry.
  • Experience with gene expression analysis by qPCR.
  • Experience working with fibroblasts and immune cells, including T cells, B cells, and monocytes.