Bioconjugate AOC/ADC Lead Scientist

Ampersand Biomedicines

Watertown (MA)

On-site

USD 100,000 - 143,000

Full time

14 days+

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Benefits offered by this job

Healthcare coverage
Annual incentive program
Retirement benefits
Broad range of benefits

Job summary

Ampersand Biomedicines is seeking a highly motivated scientist with a background in antibody-oligonucleotide/drug conjugate (AOC/ADC) and protein sciences to contribute to the discovery and development of AND-Body™ Therapeutics. This role emphasizes creating and analyzing new antibody modalities to develop biologic therapies targeted at specific tissues.

The role involves cross-functional collaboration, project leadership with CRO partners, and integrating biophysical/biochemical analyses to

Qualifications

  • PhD in Biochemistry, Chemical Biology, or related field with 2+ years of experience.
  • Background in AOC/ADC, bioconjugation, and oligonucleotide therapeutics preferred.
  • Experience with protein analytics and mass spectrometry.
  • Hands-on mammalian cell culture and plasmid transfection.
  • Experience managing CROs and communicating results clearly.

Responsibilities

  • Collaborate with cross-functional teams to develop AOC/ADC biomolecules for targeted tissue delivery.
  • Co-lead AOC/ADC projects to advance therapeutic candidates with CRO collaborators.
  • Supervise study design and data interpretation for in vitro and in vivo work.
  • Develop platform for biophysical and biochemical analyses of antibody modalities.

Skills

AOC expertise
siRNA design
antibody engineering
bioconjugation chemistry
oligonucleotide therapeutics
protein analytics
mass spectrometry
DLS
cell culture
transfection
CRO management

Education

PhD in Biochemistry
PhD in Chemical Biology
Doctorate not required in exceptional cases

Tools

ÄKTA chromatography
SEC
HIC
IEX
Mass spectrometry
DLS

Job description

Ampersand Biomedicines is seeking a highly motivated scientist with a background in antibody-oligonucleotide/drug conjugate (AOC/ADC) and protein sciences to contribute to the discovery and development of AND-Body™ Therapeutics. This role emphasizes creating and analyzing new antibody modalities to develop biologic therapies targeted at specific tissues.

The role involves cross-functional collaboration, project leadership with CRO partners, and integrating biophysical/biochemical analyses to

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