Biochemical Assay Scientist - HTS & AlphaScreen

Pliant Therapeutics; South San Francisco (CA); Presencial; USD 125.000 - 138.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Benefits

Equity

Annual bonus

Descripción de la vacante

Pliant Therapeutics in South San Francisco seeks an Associate Scientist I to develop, optimize and run biochemical binding assays, focusing on AlphaScreen/AlphaLISA formats. You will own assays from qualification to screening, generating potency data to guide medicinal chemistry decisions.

This hands-on role reports to SVP, Research in South San Francisco. The candidate will design and optimize assays, transfer to high-density formats, and support SAR efforts.

Formación

• BS with 7+ years or MS with 5+ years in biopharmaceuticals.
• Hands-on AlphaScreen/AlphaLISA assay development and troubleshooting.
• Developing/validating biochemical binding assays for HTS in 384- or 1536-well formats.
• Experience with liquid handlers and plate readers used for Alpha detection.
• Familiarity with high-content imaging and data analysis tools.

Responsabilidades

• Design and optimize AlphaScreen/AlphaLISA proximity assays.
• Miniaturize and transfer assays to 384- and 1536-well formats for screening.
• Support cell-based assays, including culture and imaging analysis.
• Execute medium- to high-throughput screening campaigns and dose-response profiling.
• Identify assay interference and validate results with orthogonal formats.
• Maintain ELN records and write SOPs/report results for teams.

Conocimientos

AlphaScreen

AlphaLISA

HTRF

Plate readers

Cell culture

Data analysis

Python

Assay development

Biomek

Operetta CLS

Educación

Bachelor's degree in Biochemistry/ Biology/ Chemistry or related field

Master's degree in Biochemistry/ related field

Herramientas

Biomek

Tempest

EnVision

PHERAstar

Operetta CLS

Descripción del empleo

Pliant Therapeutics in South San Francisco seeks an Associate Scientist I to develop, optimize and run biochemical binding assays, focusing on AlphaScreen/AlphaLISA formats. You will own assays from qualification to screening, generating potency data to guide medicinal chemistry decisions.

This hands-on role reports to SVP, Research in South San Francisco. The candidate will design and optimize assays, transfer to high-density formats, and support SAR efforts.