Biochemistry Lead — Assay Development & Hit Discovery

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 100,000 - 127,000; Full time

Job summary

Flagship Labs 111 Inc. in Cambridge, MA is seeking an independent and motivated lab scientist with deep understanding of biochemical and biophysical assay design to join the Biochemistry team.

This role will lead assay development, target engagement studies, and binding characterization for small molecules, heterobifunctionals, and related modalities, working closely with chemistry and biology to inform hit-to-lead optimization and mechanism-of-action questions.

Qualifications

• MS or PhD in Biochemistry, Chemical Biology, Enzymology, or a related field.
• MS and at least 8 years of relevant academic or industry experience.
• PhD and 0-2 years of relevant academic or industry experience.
• Deep understanding of protein chemistry and biophysics, with hands-on experience working with small-molecule compounds.
• Demonstrated ability to develop and troubleshoot biochemical assays independently.
• Excellent communication skills and the ability to work cross-functionally.
• A high degree of scientific independence, motivation, and solutions-oriented thinking.
• Comfort operating in a fast-paced environment with shifting priorities.
• Experience working with CROs is a plus.

Responsibilities

• Lead and execute biochemical assay development to monitor protein/ligand and protein/protein interactions
• Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs
• Drive protein purification and QC processes to support ongoing discovery efforts
• Set up and run high-throughput assays, troubleshooting independently to keep programs moving
• Partner with contract research organizations as needed to extend internal capacity
• Collaborate cross-functionally and contribute scientific input across multiple concurrent projects

Skills

Biochemistry

Biophysics

Assay development

Small-molecule chemistry

Communication

Education

MS in Biochemistry / Chemical Biology / Enzymology

PhD in Biochemistry / Chemical Biology / Enzymology

Job description

Flagship Labs 111 Inc. in Cambridge, MA is seeking an independent and motivated lab scientist with deep understanding of biochemical and biophysical assay design to join the Biochemistry team.

This role will lead assay development, target engagement studies, and binding characterization for small molecules, heterobifunctionals, and related modalities, working closely with chemistry and biology to inform hit-to-lead optimization and mechanism-of-action questions.