Bench Scientist, Developability & Antibody Analytics (IND)

BigHat Biosciences; San Mateo (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

BigHat Biosciences is seeking a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late-stage candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role with potential, but no guarantee, of conversion to full-time.

You'll spend the majority of time at the bench executing complex stability studies. Responsibilities include leading dose solution studies, developing sensitive analytical methods, and supporting

Qualifications

• PhD in Biochemistry or related field with 5+ years in industry.
• Develop/optimize sensitive chromatography-based methods.
• Biophysical characterization: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS.
• Translate complex data into actionable conclusions.

Responsibilities

• Lead, design, and execute in-use dose solution studies for drug compatibility.
• Develop highly sensitive protein characterization methods (qSEC, RP-HPLC, CEX, particle counting).
• Support late-stage characterization including formulation screening, stress testing, and peptide mapping.
• Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs.
• Communicate with and manage external CROs for testing and analytics.
• Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization.
• Proactively identify and scope state-of-the-art analytical tools and developability technologies.

Skills

Analytical chromatography methods

Biophysical antibody characterization

Data interpretation & communication

Adaptability & learning new tech

Education

PhD in Biochemistry or related field

Job description

BigHat Biosciences is seeking a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late-stage candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role with potential, but no guarantee, of conversion to full-time.

You'll spend the majority of time at the bench executing complex stability studies. Responsibilities include leading dose solution studies, developing sensitive analytical methods, and supporting