Senior Scientist, Developability [Contract] Lab Science San Mateo, CA

BigHat; San Mateo (CA); On-site; USD 120,000 - 150,000; Part time

Job summary

BigHat Biosciences is seeking a hands-on Senior Scientist for Developability on a 12‑month contract in San Mateo, CA. The role focuses on IND‑enabling developability assessments for late‑stage candidates from the Milliner Platform, with most time at the bench doing complex stability studies.

You will design and execute analytical methods for protein characterization, manage CROs, and interpret data to guide lead candidate advancement across programs.

Qualifications

• PhD in Biochemistry or relevant discipline with 5+ year(s) of industry experience; exceptional non‑PhD candidates with deep bench experience will be considered.
• Experience developing and optimizing sensitive analytical chromatography‑based methods is a must.
• Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE‑SDS, DLS, DSF, ELISA, LC‑MS.
• Track record of translating complex data into clear results and recommended actions.
• Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.

Responsibilities

• Lead, design, and execute in‑use dose solution studies to assess drug compatibility with administration materials.
• Develop highly sensitive protein characterization methods (qSEC, RP‑HPLC, CEX, particle counting, etc) for assessing drug quality and recovery.
• Support late‑stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.
• Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
• Communicate with and manage external CROs for testing and analytics.
• Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization.
• Proactively identify and scope state‑of‑the‑art analytical tools and developability technologies.

Job description

Senior Scientist, Developability [Contract]

Department: Lab Science

Employment Type: Contract / Temp

Location: San Mateo, CA

Description

The role: BigHat Biosciences is looking for a hands‑on, bench‑driven scientist to perform IND‑enabling developability assessments on late stage drug candidates from our Milliner Platform for AI‑designed therapeutics. This is a lab‑based 12-month contract role, with the possibility but no guarantee of conversion to full‑time position. You'll spend the majority of your time at the bench executing complex stability studies.

Key Responsibilities

• Lead, design, and execute in‑use dose solution studies to assess drug compatibility with administration materials.
• Develop highly sensitive protein characterization methods (qSEC, RP‑HPLC, CEX, particle counting, etc) for assessing drug quality and recovery.
• Support late‑stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.
• Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
• Communicate with and manage external CROs for testing and analytics.
• Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization.
• Proactively identify and scope state‑of‑the‑art analytical tools and developability technologies.

Skills Knowledge and Expertise

• PhD in Biochemistry or relevant discipline with 5+ year(s) of industry experience; exceptional non‑PhD candidates with deep bench experience will be considered.
• Experience developing and optimizing sensitive analytical chromatography‑based methods is a must.
• Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE‑SDS, DLS, DSF, ELISA, LC‑MS.
• Track record of translating complex data into clear results and recommended actions.
• Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.