Associate Scientist II, Protein Sciences

Alnylam Pharmaceuticals; United States; On-site; USD 68,000 - 101,000; Full time

Job summary

Alnylam Pharmaceuticals in Cambridge, MA seeks an Associate Scientist-II to join the protein sciences team. The role focuses on protein production, purification, and conjugation with cross-functional collaboration across biology, chemistry, and pharmacology.

This lab-based, onsite position requires independence and motivation to drive multiple projects forward. The candidate should have experience in protein purification, bioconjugation, and analytical methods; familiarity with UV-Vis, HPLC, and

Qualifications

• BS/MS in chemistry, biochemistry, or a related field with 0–1 years of lab experience.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV-Vis spectrometry.

Responsibilities

• Deliver and validate proteins and protein conjugates at production scales.
• Design, plan, and perform protein conjugation experiments for in vitro and in vivo evaluations.
• Support purification, buffer exchange, and QC of protein conjugates using UV-Vis spectroscopy and HPLC.
• Maintain laboratory infrastructure and collaborate with cross-functional teams.

Skills

Protein purification

Bioconjugation chemistry

Analytical techniques

HPLC

UV-Vis spectrometry

AKTA systems

Team collaboration

Independent work

Education

BS/MS in chemistry/biochemistry or related

Tools

Agilent HPLC

ÄKTA

TFF

Job description

Overview

We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein purification, bio conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities. This lab-based position is onsite and will be located in Cambridge, MA.

Key Responsibilities

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
• Support the purification, buffer exchange, characterization, and QC of protein and oligonucleotide conjugates by utilizing UV-Vis spectroscopy and HPLC
• Contribute to the maintenance of laboratory infrastructure and equipments.
• Support group organization, productivity, and expertise through collaboration and idea exchange.
• Assist in optimizing inventory system for proteins and protein conjugates.
• Meet quality, quantity, and timeline expectations for all assigned projects.
• Support discovery efforts in protein sciences.
• Maintain accurate and complete electronic notebook records.
• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• BS/MS degree in chemistry, chemical engineering, biochemistry, or a related field with 0-1 years of relevant laboratory experience in a biopharma or academic setting.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV-Vis spectrometry.
• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy)
• Experience developing new chromatographic methods is a plus.
• Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
• Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
• Effective written and oral communication skills.

About Alnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401kwith a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

U.S. Pay Range

$67,600 - $101,400 USD