Senior Associate Scientist, Lab Automation Engineering

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 94,000 - 127,000; Full time

Job summary

Alnylam Pharmaceuticals seeks a Lab Automation Scientist/Engineer to implement automated, robotic solutions across its drug discovery platform, from target discovery to lead selection. The role focuses on scalable screening platforms, high-throughput workflows, and transcriptional profiling, including single-cell and spatial applications.

You will optimize ex vivo sample-processing on HighRes, onboard JANUS/Beckman systems, and transition manual workflows to robotic platforms, collaborating with

Qualifications

• S. or MS degree in Bioengineering, Engineering, Biochemistry, Molecular Biology, or related field.
• 4+ years of hands-on experience operating and programming robotics platforms.
• Experience with liquid handlers and integrated platforms such as PerkinElmer, HighRes Cellario, and Beckman Coulter.

Responsibilities

• Optimize, troubleshoot, and stabilize ex vivo sample-processing methods on the HighRes platform.
• Collaborate with cross-functional scientists to streamline ex vivo sample-processing workflows.
• Onboard and develop automated methods on the new PE JANUS and Beckman liquid-handling systems.
• Lead the transition of two manual workflows to robotic liquid-handling platforms.
• Perform maintenance and troubleshooting for the integrated HighRes system and associated processes.
• Serve as a liaison between external vendors and cross-functional site stakeholders.
• Train users and provide ongoing support for existing robotic platforms.

Skills

Robotics operation

Experiment workflows

Education

S. or MS degree in Bioengineering, Engineering, Biochemistry, Molecular Biology, or related field

Tools

PerkinElmer

HighRes Cellario

Beckman Coulter

Job description

Overview

We seek a passionate, experienced, and creative Lab Automation Scientist or Engineer to drive implementation of automated and robotic solutions across our drug discovery platform. The candidate will become an integral member of a multidisciplinary team advancing novel RNAi therapeutic programs from target discovery through drug candidate lead selection. The primary objectives of the team are to develop highly scalable screening platforms and protocols to continually increase both throughput and decision-enabling content. The successful candidate will implement high-throughput workflows incorporating liquid- and plate-handling robotics in support of diverse application areas, including in vitro screening, ex-vivo sample processing, and high-throughput RNA-seq, including transcriptional profiling, spatial and single-cell applications.

Responsibilities

• Optimize, troubleshoot, and stabilize ex vivo sample-processing methods on the HighRes platform.
• Collaborate with cross-functional scientists to streamline ex vivo sample-processing workflows.
• Onboard and develop automated methods on the new PE JANUS and Beckman liquid-handling systems.
• Lead the transition of two manual workflows to robotic liquid-handling platforms.
• Perform maintenance and troubleshooting for the integrated HighRes system and associated processes.
• Serve as a liaison between external vendors and cross-functional site stakeholders.
• Train users and provide ongoing support for existing robotic platforms.

Qualifications

• S. or M.S. degree in Bioengineering, Engineering, Biochemistry, Molecular Biology, or related field
• 4+ years of hands-on experience operating and programming robotics platforms.
• Ability to understand diverse and complex workflows on liquid- and plate- handling systems, including the sources and statistical assessment of unwarranted assay variance
• Experience with liquid handlers and integrated platform such as PerkinElmer, HighRes Cellario, and Beckman Coulter.

About Alnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's CandidatePrivacy Noticeregarding how Alnylam handles Personal Data you provide with your application for employment.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:https://www.alnylam.com/careers

U.S. Pay Range

$93,500 - $126,500 USD