Senior Associate Scientist, Delivery Technology

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 80,000 - 120,000; Full time

Benefits offered by this job

Comprehensive benefits package

Onsite lab-based role

Job summary

Alnylam Pharmaceuticals is seeking a Senior Associate Scientist for our onsite Cambridge, MA lab-based team. You will support ligand discovery by performing key experiments, screening, and characterization with project leads.

The role emphasizes hands-on molecular biology, cell-based assays, and NGS workflows. You will maintain rigorous records, collaborate with cross-functional teams, and contribute to data analysis and internal presentations.

Qualifications

• BS/MS in Biology or related field with 3–6 years of industrial experience.
• Familiarity with flow cytometry and NGS library preparation required.
• Hands-on experience with PCR, cloning, and DNA/RNA extraction.
• Experience with mammalian cell culture and cell-based assays desirable.
• Direct experience with single B cell isolation and screening technologies is a plus.

Responsibilities

• Support ligand discovery campaigns by executing key experiments for discovery, screening, and characterization.
• Perform high-throughput screening and selection using cell-based assay.
• Execute NGS workflows, including library preparation from single cells.
• Perform standard molecular biology techniques, including PCR, plasmid preparation, and cloning.
• Run and assist in developing automated, high-throughput screening assays to characterize ligand properties.
• Maintain detailed records of all experimental work and data in electronic lab notebooks.
• Collaborate with cross-functional team to ensure project goals are met.
• Assist in data analysis, interpretation, and preparation of internal meeting presentations.

Skills

Flow cytometry

NGS library prep

PCR

Cloning

Mammalian cell culture

Single B cell isolation

Education

BS/MS in Biology or related field

Tools

NGS workflows

Cell-based assay platforms

Job description

Overview: The Research Department at Alnylam is seeking a motivated and skilled Senior Associate Scientist to join our innovative targeted delivery team. The successful candidate will provide critical hands-on support for ligand discovery projects. This role offers an excellent opportunity to work with cutting-edge technologies, contribute to the development of novel therapeutics, and grow within a dynamic and collaborative research environment.

This is an onsite lab-based position and will be primarily located in Cambridge, MA.

Key Responsibilities

• Support ligand discovery campaigns by executing key experiments for ligand discovery, screening, and characterization under the guidance of project leads.
• Perform high-throughput screening and selection using cell-based assay.
• Execute Next-Generation Sequencing (NGS) workflows, including library preparation from single cells.
• Perform standard molecular biology techniques, including PCR, plasmid preparation, and cloning.
• Run and assist in the development of automated, high-throughput screening assays to characterize ligand properties such as affinity, specificity, and internalization.
• Maintain detailed and accurate records of all experimental work and data in electronic lab notebooks.
• Collaborate closely with other members of the cross-functional team to ensure project goals are met.
• Assist in data analysis, interpretation, and the preparation of presentations for internal meetings.

Qualifications

• • BS/MS in Biology, Cell/Molecular Biology or related field with 3-6 years of work experience, preferable in an industrial setting. Familiarity with flow cytometry and NGS library preparation is required.
  • Hands-on experience with standard molecular biology techniques (e.g., PCR, cloning, DNA/RNA extraction) is required.
  • Experience with mammalian cell culture and cell-based assays is highly desirable.
  • Direct experience with single B cell isolation and screening technologies is a significant plus.

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U.S. Pay Range

$80,000.00 - $120,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.