Associate Scientist II, Protein Sciences

Alnylam Pharmaceuticals, Inc.; Cambridge, Northern (MA, KY); Hybrid; USD 65,000 - 90,000; Full time

Job summary

Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking an associate scientist-II to join our protein sciences team to advance protein production and conjugation.

The candidate should be independent, motivated, and capable of collaborating with biologists, chemists, and pharmacologists to deliver high-quality proteins and conjugates for multiple therapeutic modalities in a fast-paced, entrepreneurial environment.

Qualifications

• BS/MS in chemistry, biochemistry, or related field with 0–1 years lab experience.
• Experience with bioconjugation chemistry and analytical techniques.
• Experience with chromatography and protein analysis methods.

Responsibilities

• Deliver and validate proteins and conjugates at production scales.
• Plan and perform protein conjugation experiments for in vitro and in vivo evaluations.
• Support purification, buffer exchange, QC of protein conjugates using UV-Vis spectroscopy and HPLC.
• Maintain laboratory infrastructure and equipments.
• Collaborate with cross-functional teams and communicate results.
• Assist in optimizing inventory for proteins and conjugates.
• Meet quality, quantity, and timeline expectations for projects.

Skills

Protein purification

Bioconjugation

Analytical techniques

UV-Vis spectroscopy

HPLC

Team collaboration

Effective communication

Education

BS/MS degree in chemistry, biochemistry or related field

Tools

Agilent HPLC systems

ÄKTA

TFF

UV-Vis spectrometry

Job description

United States

Overview

We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein purification, bio conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities

This lab-based position is onsite and will be located in Cambridge, MA.

Key Responsibilities

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
• Support the purification, buffer exchange, characterization, and QC of protein and oligonucleotide conjugates by utilizing UV-Vis spectroscopy and HPLC
• Contribute to the maintenance of laboratory infrastructure and equipments.
• Support group organization, productivity, and expertise through collaboration and idea exchange.
• Assist in optimizing inventory system for proteins and protein conjugates.
• Meet quality, quantity, and timeline expectations for all assigned projects.
• Support discovery efforts in protein sciences.
• Maintain accurate and complete electronic notebook records.
• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• BS/MS degree in chemistry, chemical engineering, biochemistry, or a related field with 0-1 years of relevant laboratory experience in a biopharma or academic setting.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV-Vis spectrometry.
• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy)
• Experience developing new chromatographic methods is a plus.
• Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
• Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
• Effective written and oral communication skills.

About Alnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.