Associate Scientist II - Bio Process Purification Development

AbbVie; South San Francisco (CA); On-site; USD 75,000 - 143,000; Full time

Benefits offered by this job

Medical/dental/vision insurance

401(k) plan

Paid time off

Job summary

AbbVie Inc. in South San Francisco is seeking an Associate Scientist II to join the Bio Process Purification Development team.

The role focuses on developing and scaling purification processes for GMP production of clinical material, with emphasis on strong documentation and collaboration in a fast-paced lab setting. The candidate will contribute to process improvements, transfer plans to GMP manufacturing, and the evaluation of novel bioprocess technologies.

Qualifications

• Bachelor’s degree in Chemical Engineering, Biochemistry, Chemistry, or related field with typically 3+ years of experience or MS with 0-2 years in industry.
• Detail-oriented with ability to follow written protocols and safety procedures and maintain accurate records.
• Ability to analyze and critique experimental results and note significant deviations.
• Proven ability to collaborate within and outside of the group and learn new techniques.

Responsibilities

• Support development, optimization, and scale-up of purification processes in lab and scale-up settings.
• Support transfer of purification processes to GMP manufacturing for clinical material production.
• Execute routine purification development operations from harvest to UF/DF following protocols.
• Record observations and results with complete traceable datasets and batch records.
• Prepare buffers (500 L batches) following batch records and maintain lab safety procedures.
• Perform analytical measurements using HPLC and UV-vis instrumentation.
• Collaborate within the team to meet project goals and evaluate novel bioprocess technologies.

Skills

Attention to detail

Follow protocols

Data analysis

Collaboration

Learning new techniques

Bioprocess concepts

Planning and organization

Scientific communication

Microsoft Office

Education

Bachelor’s in Chemical Engineering

MS in related field

Tools

Microsoft Office

Job description

Associate Scientist II - Bio Process Purification Development

• Full-time
• Salary Min: 75000
• Salary Max: 142500
• Workday Global Grade: 15
• Compensation: USD 75,000 - USD 142,500 - yearly

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure.This role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.

As one of CMC purification development associate scientists, you will work in the CMC purification team to develop robust, phase-appropriate processes for drug substance GMP production to enable human clinical studies and eventual licensure. This position is an onsite role in a lab-based function. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment with daily face-to-face interactions between scientists.

Responsibilities

• Support development, optimization, and scale-up of purification processes through lab-based and -scale up lab operation activities
• Support transfer of purification processes to GMP manufacturing for clinical material production
• Execute routine purification development operations from harvest to UF/DF following established protocols, independently after appropriate training, and generate reliable and consistent results
• Analyze and critique experimental results, document and promptly communicate significant deviations or unexpected results
• Prepare small to large (500L) batches of buffer solutions following batch record recipe
• Support scale up lab activities including preparation and execution
• Perform routine analytical measurements using HPLC and UV-vis instrumentation
• Accurately record experimental observations and results at the time of execution; maintain complete, traceable data sets and batch records, including instrument files and analytical results, in electronic notebooks, databases, and Excel files in accordance with established documentation procedures and timelines
• Perform general lab maintenance including cleanliness, equipment maintenance and maintaining inventory
• Follow applicable laboratory and scale up plant safety procedures and standard operating procedures (SOPs), complete required training before performing assigned activities
• Collaborate within the team in order to follow best practices and meet project goals
• Participate in the evaluation of novel, advanced bioprocess technologies that are in line with the group’s strategy
• Learn and understand new experimental techniques
• Must be comfortable with physical activities of constant standing, walking, sitting and occasionally lifting up to 50 Ibs
• Author technical reports and presentations including preparing verbal updates and presentations at group meetings.

Qualifications

• Bachelor’s degree in Chemical Engineering, Biochemistry, Chemistry, or a closely related field, with typically 3+ years of related experience or MS degree with 0-2years of relevant industry experience.
• Must have excellent attention to detail, the ability to follow written experimental protocols and safety procedures, and the ability to maintain accurate, complete, and traceable written records
• Able to analyze and critique experimental results and note significant deviations
• Able to work collaboratively within and outside of the group
• Able to learn and understand new experimental techniques
• Has a strong understanding of bioprocess engineering concepts
• Has strong planning and analytical skills
• Has excellent interpersonal and communication skills
• Proficient in scientific writing skills and verbal communication including scientific data presentations
• Proficient in Microsoft Office and have the ability to learn new software applications

Preferred

• Has hands on experience with executing antibody or antibody-like molecule purification techniques including resin chromatography (affinity, CEX, AEX, MMC), depth filtration, virus filtration, membrane chromatography, and TFF operations.
• Has hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory scale
• Understanding of analytical techniques, such as HPLC, LAL, and ELISA
• Has hands on experience with high-throughput technologies and automation
• Has hands on experience with high-throughput technologies and automation

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may bemodified in thefuture.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

This job is eligible toparticipate in our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremains in the Company'ssoleandabsolutediscretion unless and until paid andmay bemodified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.