Senior Scientist I, Biologics Analytical R&D, CMC Biologics Development

AbbVie Inc.; Chicago (IL); On-site; USD 150,000 - 210,000; Full time

Job summary

AbbVie Biologics Analytical Research & Development in the United States is seeking a senior scientist with deep expertise in mass spectrometry-based characterization of biologics. The role emphasizes leading analytical development strategies, building extended characterization methods, and delivering data-driven insights to accelerate development programs.

The incumbent will collaborate across disciplines, contribute to publications, and support regulatory filings while operating in a

Qualifications

• PhD in analytical chemistry, biochemistry, biology or related field.
• Hands-on MS-based characterization of biologics including intact/subunit analysis.
• Strong knowledge of MS-coupled chromatographic methods and separation techniques.
• Familiarity with CE, icIEF, biophysical and binding assays is a plus.
• Strong written and oral communication and time management skills.
• Ability to work independently and collaboratively across functions.

Responsibilities

• Serve as SME in BioARD and lead phase-appropriate analytical development strategies for biologics characterization.
• Build out extended characterization methods to support in-process analytics and stability testing.
• Contribute data-driven analyses to project teams and drive programs through milestones.
• Provide technical oversight and independent execution in cross-functional settings.
• Collaborate on development of new products or technologies and share findings.
• Author and review lab notebooks, reports, and regulatory documents; present at conferences.

Skills

Mass spectrometry

Biologics characterization

MS techniques

Scientific communication

Independent work

Education

PhD in relevant field

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn,Facebook,Instagram,XandYouTube.

Job Description

AbbVie Biologics Analytical Research & Development (Biologics Analytical R&D) is a global analytical sciences organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products.

Our scope includes AbbVie's diverse pipeline of innovative therapeutic biologic medicines and spans from the selection of Discovery candidate molecules through the transition of analytical methods and testing to commercial labs to support product launch. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Biologics Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies.

Key Responsibilities

• Act as a subject matter expert in BioARD, lead phase-appropriate analytical development strategies for biologics characterization including ADC, PDC, AOC, fusion proteins, multi-specific antibodies, and other novel modalities.
• Execute the buildout of biotherapeutics extended characterization methods to facilitate in-process analytics, batch release/stability, RS qualification, and comparability study.
• Make lab-based, data-driven, and phase-appropriate contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.
• Represent key area function in cross-functional project teams, provide hands-on analytical support, technical oversight to portfolios. The ability to independently drive scientific investigations.
• Collaborate and integrate scientific objectives associated with development of new/improved products or technology; contribute to scientific exchange and publications.
• Author, review lab notebook, analytical report, and analytical sections of regulatory filings. Primary author of external publications, presentations, and patents. Present at leading scientific conferences.

Qualifications

• PhD in scientific discipline (e.g., Analytical Chemistry, Biochemistry, or Biology); BS or equivalent education and extensive 10+ years of experience; MS or equivalent education with 8+ years of experience.
• Direct and hands‑on experience in mass spectrometry‑based characterization of biologics, including intact/subunit analysis, peptide mapping, disulfide bond mapping, etc.
• Working knowledge of mass spectrometry coupled chromatographic separation techniques and complementary separation‑based analytical methods, including SEC, HIC, HILIC, RPLC, etc.
• Familiarity with biologics CE, icIEF, biophysical assays, or binding and functional assays are plus.
• Good written and oral communication skills, and time management skills.
• Ability to work independently and collaboratively across functions.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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