Associate Scientist I - Biophysical Characterization & HTS

BioPhase; Pasadena (CA); On-site; USD 96,000 - 121,000; Full time

Job summary

BioPhase is seeking an Associate Scientist I to support antibody discovery, engineering, and characterization across a preclinical biologics pipeline. The role involves hands-on experiments in mammalian cell culture, high-throughput screening, and developability assessments using flow cytometry and biophysical assays.

The ideal candidate will have strong execution and troubleshooting skills, experience with automation and data analysis tools, and the ability to work independently in a fast-paced

Qualifications

• Bachelor’s degree with 6+ years of relevant industry laboratory experience, or Master’s degree with 4+ years
• Hands-on experience with mammalian cell culture and cell-line generation
• Experience with multi-color flow cytometry and analysis software (FlowJo/OMIQ)
• Experience with high-throughput assay workflows and automated liquid handling
• Proficiency in data analysis and visualization tools (Benchling/GraphPad/Spotfire)
• Strong troubleshooting, documentation, and communication skills

Responsibilities

• Support antibody discovery, engineering, and characterization through cell-based assays and developability tests
• Execute, optimize, and troubleshoot high-throughput workflows and automated liquid handling
• Culture mammalian cells and assist with transient and stable cell-line generation
• Perform antibody screening assays including binding, competition, and reporter readouts
• Analyze and clearly communicate experimental data to cross-functional teams
• Develop data analysis and reporting workflows using scripting and informatics tools
• Maintain rigorous data integrity, sample traceability, and lab safety practices
• Assist with instrument maintenance and inventory management

Skills

Cell culture

Troubleshooting

Data analysis

Independent work

Education

Bachelor’s degree in Biological Sciences, Cell Biology, Immunology, or related

Master’s degree in related field

Tools

FlowJo

OMIQ

Benchling

GraphPad Prism

Spotfire

Job description

BioPhase is seeking an Associate Scientist I to support antibody discovery, engineering, and characterization across a preclinical biologics pipeline. The role involves hands-on experiments in mammalian cell culture, high-throughput screening, and developability assessments using flow cytometry and biophysical assays.

The ideal candidate will have strong execution and troubleshooting skills, experience with automation and data analysis tools, and the ability to work independently in a fast-paced