Associate Scientist (Dr Pereira's Lab) - Neurology

Mount Sinai; United States; On-site; USD 70,000 - 100,000; Full time

Job summary

Mount Sinai's Pereira Laboratory seeks an outstanding Associate Scientist to advance Alzheimer's disease research using animal models, human tissue, iPSCs, and bioinformatics.

Key duties include in vivo mouse work (stereotaxic injections), molecular biology, cell culture, and data analysis; training and collaboration across teams to drive scientific progress and safety compliance.

Qualifications

• Ph.D. in Biological Science or related field is required.
• Three years' experience in neurobiology research.
• Extensive experience with mouse models and stereotaxic injections preferred.
• Strong background in molecular and cell biology techniques.

Responsibilities

• Perform in vivo experiments using mouse models, including stereotaxic injections.
• Conduct molecular and cell biology experiments to support ongoing projects.
• Carry out lab techniques: cell culture, DNA/RNA isolation, fractionation, Western blotting, PCR/qRT-PCR, in situ hybridization, IHC.
• Investigate disease mechanisms and develop methods, instrumentation, and procedures.
• Design and conduct complex studies, evaluate methods and models.
• Plan studies on human or animal diseases and potential treatments.
• Provide training and guidance on procedures to staff and students.
• Collaborate with healthcare professionals and researchers to support safety standards.
• Develop research tools and methodologies to advance investigations.
• Analyze data, interpret results, and communicate findings via publications and presentations.
• Develop proposals and seek support for new research activities.
• Provide scientific recommendations and perform other related duties.

Skills

Mouse models

Stereotaxic injections

Molecular biology

Cell biology

Cell culture

DNA/RNA isolation

Western blotting

PCR/qRT-PCR

In situ hybridization

Immunohistochemical labeling

Bioinformatics

Education

Ph.D. in Biological Science or related field

Job description

The Pereira Laboratory at the Icahn School of Medicine investigates the neurobiology of Alzheimer's disease, including the selective regional and cellular vulnerability to tau pathology and neurodegeneration. We are seeking an outstanding Associate Scientist to join the lab's efforts to discover and validate novel therapeutic targets using animal models, postmortem human tissue, iPSCs, and bioinformatics.

• Perform in vivo experiments using mouse models, including stereotaxic injections.
• Conduct molecular and cell biology experiments to support ongoing research projects.
• Perform laboratory techniques, including cell culture, DNA/RNA isolation, cellular fractionation, Western blotting, PCR/qRT-PCR, in situ hybridization, and immunohistochemical labeling.
• Conduct research to develop methodologies, instrumentation, and procedures for medical applications, including analyzing data and presenting findings.
• Design and conduct complex research studies, evaluating alternative methods, computational models, and experimental approaches.
• Plan and conduct studies investigating human or animal diseases, preventive methods, and potential treatments.
• Assist in clinical laboratory operations, as needed.
• Follow established laboratory safety procedures to prevent contamination and ensure compliance with safety standards.
• Provide training and guidance on medical and laboratory procedures to physicians, residents, students, and research staff.
• Collaborate with healthcare professionals, researchers, and other stakeholders to support research initiatives and health safety standards.
• Develop research tools, techniques, and methodologies to support scientific investigations.
• Identify research questions, develop hypotheses, and establish methodologies for evaluating experimental results.
• Analyze and interpret research findings and communicate results through scientific publications and presentations.
• Develop research proposals and seek support for new and ongoing research activities.
• Provide scientific recommendations to support research activities and project objectives.
• Perform other related duties.

• Ph.D. in Biological Science or related field
• Three years' experience
• Highly Preferred Experience: Extensive experience working with mouse models, including performing stereotaxic injections.
• Strong background in molecular and cell biology.
• Experience with laboratory techniques, including cell culture, DNA/RNA isolation, cellular fractionation, Western blotting, PCR/qRT-PCR, in situ hybridization, and immunohistochemical labeling.
• Strong interest in neurodegeneration highly preferred.
• Demonstrated self-motivation, enthusiasm, and scientific rigor.
• Ability to work independently at the bench.