Staff Research Associate II - Neurology

University of California; Los Angeles (CA); On-site; USD 45,000 - 73,000; Full time

Job summary

The Patel lab at UCLA Health seeks an experienced laboratory research technician to study brain clearance pathways in Alzheimer's disease using mouse models and cell culture systems. Under supervision, the Staff Research Associate will conduct experiments, maintain transgenic lines, and perform brain sectioning, histology, IHC, IF, and data analysis.

Experience with rodent surgeries and ImageJ is preferred.

Qualifications

• Bachelor's degree in biological science or related field with lab experience.
• 2+ years neuroscience or brain research experience.
• 2+ years experience with mouse survival surgeries and/or behavioral testing.
• Ability to learn new software or lab techniques as needed.
• Ability to read and interpret scientific articles to stay current.
• Excellent verbal and written fluency in English.
• Ability to prepare tissues for histological stains (cryostat/microtome).
• Experience with viral vectors and modern molecular biology tools is preferred.
• Familiarity with microscopy techniques (epifluorescence, confocal).

Responsibilities

• Support studies in mouse models and cell culture for brain clearance pathways.
• Develop and maintain transgenic mouse lines and perform brain sectioning.
• Conduct histology, immunohistochemistry and immunofluorescence assays.
• Analyze data and assist with experiments related to neurodegeneration.
• Assist with rodent survival surgeries and behavioral testing as needed.

Skills

Mouse handling

Histology

Immunohistochemistry

Immunofluorescence

Cell culture

Image analysis (ImageJ)

Data analysis

Reading scientific literature

Education

Bachelor's degree in biological science

Tools

Cryostat

Microtome

Epifluorescence microscope

Confocal microscope

Job description

Description

The Patel lab is seeking an experienced laboratory research technician to support its main mission of investigating the role of brain clearance pathways in Alzheimer's disease and related dementias in animal models. Under the general supervision of the PI, the Staff Research Associate will conduct studies in mouse models and cell culture systems investigating the role of meningeal lymphatics and other related brain clearance pathways in neurodegeneration. Technical support is needed to develop and maintain complex transgenic mouse lines and to perform experiments involving brain sectioning, histology, immunohistochemistry, immunofluorescence, and data analysis. Additional experience with rodent survival surgeries, cell culture, and image analysis platforms (such as ImageJ) is preferred. Familiarity with high complexity transcriptomic datasets is also preferred. A bachelor's degree and some lab experience are required.

Hourly salary range:32.79 -52.75

Qualifications

• BS or BA in biological science or related experience
• 2+ years ofPrevious work in neuroscience or brain research
  fields
• 2+ years of previousexperience with mouse or rat survival
  surgeries and/or behavioral testing
• Ability to learn new software or laboratory techniques as needed
• Skill in reading and interpreting scientific journal articles in order to stay current in laboratory techniques and protocols
• Excellent verbal and written fluency in English
• Ability to cut and process tissue for histological and immunohistochemical stains using cryostat or other similar device (e.g. microtome)
• Familiarity with modern molecular biology tools and techniques, including handling viral vectors and other compounds
• Familiarity with microscopy techniques (epifluorescence, confocal)
• Ability to create and maintain records accurately.