Associate Principal Scientist, Regenerative Immunology

BioSpace; Englewood (NJ); Sur place; USD 160 000 - 215 000; Plein temps

Résumé du poste

BioSpace in the United States is seeking a Principal Scientist to lead the Thymic Regeneration Team, restoring thymic function and rejuvenating adaptive immunity.

You will develop iPSC-derived thymic epithelial cells (iTECs) and thymic organoids, and design directed-differentiation protocols to generate functional TECs from human iPSCs. The role requires a PhD or MD/PhD with 10+ years of relevant research experience in thymic biology and regenerative immunology.

Qualifications

• PhD or MD/PhD required.
• 10+ years of research experience in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology.
• Deep knowledge of thymic epithelial cell biology, iPSC differentiation, T-cell development and tissue engineering.
• Expert knowledge in experimental therapeutics and regenerative immune pipelines.

Responsabilités

• Lead a team developing iPSC-derived thymic epithelial cells and thymic organoids.
• Develop thymic regeneration concepts for immune reconstitution and rejuvenative medicine.
• Design protocols to generate TECs from human iPSCs.
• Collaborate with ICR scientists to advance immune rejuvenation.

Connaissances

Immunology

Thymic biology

iPSC differentiation

Organoid engineering

Experimental therapeutics

Translational research

Formation

PhD or MD/PhD

Outils

iPSC culture

3D organoid culture

CRISPR gene editing

RNA-seq

Flow cytometry

Immunofluorescent microscopy

Description du poste

ICR's Regenerative Immunology program is focused on regenerating the aging immune system, the decline of which underlies many of the most devastating age-related diseases. We're hiring a Principal Scientist to lead our Thymic Regeneration Team to restore thymic function and rejuvenate adaptive immunity. You'll need a deep background in immunology, thymic biology and iPSCs.

With ICR, You'll Get To

• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution and rejuvenative medicine ideas
• Design and optimize directed-differentiation protocols to generate functional, TECs from human iPSCs
• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm

Please Apply If You Have

• A PhD or MD/PhD
• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering or regenerative immunology
• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development and tissue engineering
• Expert knowledge in experimental therapeutics and the landscape of developmental pipelines of practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation

Ideally, You'll Also Have

• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection and thymic niche reconstitution
• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing and cell culture
• Experience with in vivo transplantation, humanized mouse models and assessment of functional immune reconstitution

And you'll need:

• A friendly, easygoing personality
• The ability to work in the United States without sponsorship

Salary

• Starting base pay range: $160,000/yr - $215,000/yr
• Starting additional compensation range: $10,000/yr - $20,000/yr