Senior Scientist, In Vivo Pharmacology

United Therapeutics Corporation; Boston (MA); On-site; USD 128,000 - 170,000; Full time

Job summary

United Therapeutics Corporation is seeking a Senior Scientist to lead preclinical research for iPSC-derived thymic cell therapies aimed at restoring immune function in aging and transplantation. You will design in vivo mouse studies and develop models for immune reconstitution, aging, and tolerance.

The role involves high-dimensional profiling using flow cytometry, RNA-seq, and functional assays, with collaboration across R&D and regulatory teams.

Qualifications

• PhD in immunology, stem cell biology, regenerative medicine, or related field.
• 5+ years in preclinical model development.
• Strong knowledge of thymus biology, T-cell development, and immune mechanisms.

Responsibilities

• Design and execute in vivo mouse studies assessing efficacy, safety, pharmacology, biodistribution, and mechanism of action.
• Develop relevant models for immune reconstitution, aging, and tolerance.
• Perform high-dimensional immune profiling using flow cytometry, RNA-seq, and functional assays.
• Collaborate with research, process development, and regulatory teams.
• Generate data supporting candidate selection and IND-enabling studies.
• Interpret and communicate results.
• Mentor junior staff.
• Evaluate emerging literature and therapeutic opportunities.

Skills

Flow cytometry

qPCR

RNA-seq

Data analysis

In vivo mouse models

Communication

Mentoring

Education

PhD in immunology, stem cell biology, regenerative medicine, or related field

Tools

Histology

Immunohistochemistry

Job description

Role

Senior Scientist leading preclinical research for iPSC-derived thymic cell therapies aimed at immune restoration in aging, immunodeficiency, and transplantation.

Responsibilities

• design and execute in vivo mouse studies assessing efficacy, safety, pharmacology, biodistribution, and mechanism of action
• develop relevant models for immune reconstitution, aging, and tolerance
• perform high-dimensional immune profiling using flow cytometry, RNA-seq, and functional assays
• collaborate with research, process development, and regulatory teams
• generate data supporting candidate selection and IND-enabling studies
• interpret and communicate results
• mentor junior staff
• evaluate emerging literature and therapeutic opportunities

Requirements

• PhD in immunology, stem cell biology, regenerative medicine, or related field
• 5+ years in preclinical model development
• strong knowledge of thymus biology, T-cell development, and immune mechanisms
• hands-on experience in rodent handling, immunological assays, flow cytometry, qPCR, histology, and data analysis
• excellent communication skills

Preferred

experience in nonclinical development, IND-enabling studies, regulatory writing, and familiarity with immunosenescence, tumor immunology, autoimmunity, and transplantation immunology.

Location

onsite in Cambridge, MA with occasional weekend work.

Compensation

$127,500 - $170,000, based on experience.