Senior Scientist, In Vivo Immunology & Thymic Research

United Therapeutics Corporation; Boston (MA); Vor Ort; USD 128.000 - 170.000; Vollzeit

Zusammenfassung

United Therapeutics Corporation is seeking a Senior Scientist to lead preclinical research for iPSC-derived thymic cell therapies aimed at restoring immune function in aging and transplantation. You will design in vivo mouse studies and develop models for immune reconstitution, aging, and tolerance.

The role involves high-dimensional profiling using flow cytometry, RNA-seq, and functional assays, with collaboration across R&D and regulatory teams.

Qualifikationen

• PhD in immunology, stem cell biology, regenerative medicine, or related field.
• 5+ years in preclinical model development.
• Strong knowledge of thymus biology, T-cell development, and immune mechanisms.

Aufgaben

• Design and execute in vivo mouse studies assessing efficacy, safety, pharmacology, biodistribution, and mechanism of action.
• Develop relevant models for immune reconstitution, aging, and tolerance.
• Perform high-dimensional immune profiling using flow cytometry, RNA-seq, and functional assays.
• Collaborate with research, process development, and regulatory teams.
• Generate data supporting candidate selection and IND-enabling studies.
• Interpret and communicate results.
• Mentor junior staff.
• Evaluate emerging literature and therapeutic opportunities.

Kenntnisse

Flow cytometry

qPCR

RNA-seq

Data analysis

In vivo mouse models

Communication

Mentoring

Ausbildung

PhD in immunology, stem cell biology, regenerative medicine, or related field

Tools

Histology

Immunohistochemistry

Jobbeschreibung

United Therapeutics Corporation is seeking a Senior Scientist to lead preclinical research for iPSC-derived thymic cell therapies aimed at restoring immune function in aging and transplantation. You will design in vivo mouse studies and develop models for immune reconstitution, aging, and tolerance.

The role involves high-dimensional profiling using flow cytometry, RNA-seq, and functional assays, with collaboration across R&D and regulatory teams.