Associate Director, Oligo Development & CMC Strategy

Dyne Therapeutics; Waltham (MA); On-site; USD 159,000 - 195,000; Full time

Job summary

A biotechnology company in Waltham, MA is seeking an Associate Director of Oligonucleotide Development to lead the chemical synthesis strategy for PMO and ASO payload molecules. This role involves managing the full development lifecycle through GMP manufacture, ensuring robust and scalable processes. The ideal candidate has a PhD and over 8 years of experience in oligonucleotide development, with expertise in managing CDMOs and navigating regulatory submissions. The position requires onsite presence 4–5 days a week.

Qualifications

• PhD or equivalent in a scientific discipline and 8+ years of related experience.
• Proven track record in the chemistry and development of PMO and ASO oligonucleotides.
• Extensive experience defining and implementing CMC strategies from pre‑IND through clinical cGMP manufacturing.

Responsibilities

• Lead process development for PMO and ASO payload molecules.
• Set vision for analytical development focusing on impurity control.
• Manage technology transfer and external partner relationships.

Skills

Oligonucleotide Expertise

CMC Lifecycle Mastery

Strategic Problem Solving

Collaborative Influence

Education

Ph.D. or equivalent experience

Job description

A biotechnology company in Waltham, MA is seeking an Associate Director of Oligonucleotide Development to lead the chemical synthesis strategy for PMO and ASO payload molecules. This role involves managing the full development lifecycle through GMP manufacture, ensuring robust and scalable processes. The ideal candidate has a PhD and over 8 years of experience in oligonucleotide development, with expertise in managing CDMOs and navigating regulatory submissions. The position requires onsite presence 4–5 days a week.