Assistant Scientist - AI-Enabled Immune Digital Twin & Organ Damage Mechanistic Model

Indiana University Bloomington; Bloomington (IN); On-site; USD 85,000 - 115,000; Full time

Job summary

Indiana University Bloomington is seeking an Assistant Scientist to build AI-enabled immune digital twin and organ-damage mechanistic models. The role focuses on linking immune dynamics to organ injury in critical illness under Dr. James A.

Glazier, mapping biomarkers to model states, and delivering project milestones. You will contribute to fast, interpretable models, perform collaborations with national partners, and produce research papers and contract-ready deliverables within a team at the

Qualifications

• Ph.D. or equivalent terminal degree in quantitative, computational, or biomedical discipline.
• Programming proficiency in Python, Julia, R, or MATLAB; background in mechanistic modeling (ODE/dynamical systems, QSP, or agent-based); familiarity with inflammation, cytokine signaling, sepsis, or critical care biology.
• One year of successful postdoctoral research experience.

Responsibilities

• Develop biologically meaningful, interpretable model components linking immune-state dynamics to organ-damage risk in critical illness under the direction of Dr. James A. Glazier.
• Map clinical biomarkers to model states, define scoring criteria for digital twin ensembles, collaborate with national consortium partners, write technical publications, and prepare milestone-ready contract deliverables.

Skills

Python

Julia

R

MATLAB

Mechanistic modeling

Inflammation biology

Education

Ph.D./equivalent terminal degree (quantitative, computational, or biomedical)

Tools

ODE/dynamical systems

QSP

Agent-based modeling

Job description

Posting Details

Title

Assistant Scientist - AI-Enabled Immune Digital Twin & OrganDamage Mechanistic Model

Appointment Status

Non-Tenure Track

Department

IU Bloomington Intelligent Systems Engineering

Location

Bloomington

Position Summary

AI-Enabled Immune Digital Twin & Organ damage Mechanistic ModelScientist: Assistant Scientist; Biocomplexity Institute at IndianaUniversity Bloomington (PI: Dr. James A. Glazier)

Your primary duties will be to develop biologically meaningful,interpretable model components linking immune-state dynamics toorgan-damage risk (lung, kidney, liver) in critical illness underthe direction of Dr. James A. Glazier. You will map clinicalbiomarkers to model states, define biological scoring criteria fordigital twin ensembles, collaborate with national consortiumpartners, write technical publications, and prepare milestone-readycontract deliverables.

60% Dynamic Immune & Organ Modeling: Develop fast,interpretableODE /network/mechanistic model modules linking immune dysfunctionto organ injury; map clinical time-series and biomarkers to modelstates; formulate biological plausibility and scoringcriteria.

40% Consortium Deliverables & Research: Prepare test cases,model packages, and model cards; write research papers; presentfindings; collaborate with national consortium partners in systemsbiology and clinical data science.

Basic Qualifications

• Ph.D. or equivalent terminal degree in quantitative, computational,or biomedical discipline.
• Programming proficiency in Python, Julia, R, or MATLAB ; backgroundin mechanistic modeling ( ODE /dynamical systems, QSP, oragent-based); familiarity with inflammation, cytokine signaling,sepsis, or critical care biology.
• One year of successful postdoctoral research experience.

Department Contact for Questions

Please contact Professor James Glazier at [e-mail].

Salary and Rank

100,000/Assistant Scientist

For Best Consideration Date

11/02/2026

Posting Number

IU-101731-2026