Assistant Scientist - AI-Enabled Immune Digital Twin & Organ Damage Mechanistic Model

Indiana University; Bloomington (IN); On-site; USD 65,000 - 90,000; Full time

Job summary

Indiana University Bloomington seeks an Assistant Scientist to develop AI-enabled immune digital twin and organ-damage mechanistic models. The role advances interpretable models linking immune dynamics to organ injury across critical illness, under Dr. James A. Glazier.

Responsibilities include mapping biomarkers to states, defining scoring, collaborating with national partners, and publishing research while delivering contract milestones.

Qualifications

• Ph.D. or equivalent terminal degree in quantitative, computational, or biomedical discipline.
• Proficiency in Python, Julia, R, or MATLAB.
• At least one year of postdoctoral research experience.

Responsibilities

• Develop biologically meaningful, interpretable model components linking immune-state dynamics to organ-damage risk in critical illness.
• Map clinical biomarkers to model states and define scoring criteria.
• Collaborate with national consortium partners; write technical publications and prepare milestone-ready deliverables.
• Prepare test cases, model packages, and model cards; present findings.

Skills

Python

Julia

R

MATLAB

Mechanistic modeling

Education

Ph.D. or equivalent terminal degree in quantitative, computational, or biomedical discipline

Tools

ODE Modeling

Dynamical Systems

QSP

Agent-based Modeling

Job description

Assistant Scientist - AI-Enabled Immune Digital Twin & Organ Damage Mechanistic Model

Title Assistant Scientist - AI-Enabled Immune Digital Twin & Organ Damage Mechanistic Model

Location Bloomington

Position Summary

AI-Enabled Immune Digital Twin & Organ damage Mechanistic Model Scientist: Assistant Scientist; Biocomplexity Institute at Indiana University Bloomington (PI: Dr. James A. Glazier)

Your primary duties will be to develop biologically meaningful, interpretable model components linking immune-state dynamics to organ-damage risk (lung, kidney, liver) in critical illness under the direction of Dr. James A. Glazier. You will map clinical biomarkers to model states, define biological scoring criteria for digital twin ensembles, collaborate with national consortium partners, write technical publications, and prepare milestone-ready contract deliverables.

60% Dynamic Immune & Organ Modeling: Develop fast, interpretable ODE /network/mechanistic model modules linking immune dysfunction to organ injury; map clinical time-series and biomarkers to model states; formulate biological plausibility and scoring criteria.

40% Consortium Deliverables & Research: Prepare test cases, model packages, and model cards; write research papers; present findings; collaborate with national consortium partners in systems biology and clinical data science.

Basic Qualifications

Ph.D. or equivalent terminal degree in quantitative, computational, or biomedical discipline.

Programming proficiency in Python, Julia, R, or MATLAB ; background in mechanistic modeling ( ODE /dynamical systems, QSP , or agent-based); familiarity with inflammation, cytokine signaling, sepsis, or critical care biology.

One year of successful postdoctoral research experience.

Department Contact for Questions

Please contact Professor James Glazier at [e-mail].

For Best Consideration Date

11/02/2026

Supplemental Questions

• * Have you previously been employed with IU?
  • Yes
  • No