Analytical Development Associate Scientist — On-Site Philly

Cabaletta Bio Inc.; Philadelphia (Philadelphia County); On-site; USD 95,000 - 125,000; Full time

Benefits offered by this job

Competitive benefits

PTO

Stock option plans

Job summary

Cabaletta Bio, Inc. in Philadelphia, PA, seeks an Associate Scientist in Analytical Development to join our on-site team. You will develop, qualify, and validate analytical methods for cell therapy products, support testing at CDMOs, and drive troubleshooting across the lifecycle.

Collaboration with CMC, Quality, and external partners will be essential. The role requires a biology-based degree with 2–4 years’ experience, aseptic technique proficiency, and expertise in flow cytometry, qPCR/dPCR,

Qualifications

• Bachelor’s or master’s degree in biology or closely related discipline with 2–4 years of experience.
• Proficient in aseptic techniques for cell culture and cell-based assays.
• Strong experience in analytic techniques, including flow cytometry, qPCR/dPCR, ELISA, HPLC etc.
• Demonstrated experience with analytical method qualification and validation.
• Experience working with CDMOs and contract testing laboratories in biologics, cell and gene therapy fields.
• Familiar with GMP compliance.
• Demonstrated scientific problem-solving, critical-thinking, and communication/interpersonal skills, with attention to detail and strong organizational skills, and ability to manage multiple priorities in a fast-paced environment.

Responsibilities

• Participate in the development, optimization, and qualification/validation of analytical methods, as required to evaluate safety, purity, identity, potency of lentiviral vectors, cell therapy product and other advanced modalities, in compliance with relevant regulatory guidelines
• Perform analytical testing, supporting method development and qualification activities.
• Participate in technical oversight and serve as subject matter expert (SME) to CDMOs and external laboratories.
• Assist monitoring/trending of assay performance, investigation of assay deviations, out-of-specification, out-of-trend and out-of-expectation results at Analytical Development and external partners.
• Provide analytical expertise to Process Development, Manufacturing Sciences and Technology (MSAT), Quality & Compliance, and Quality Control
• Author and review method protocols, reports, and supporting documentation, ensuring compliance with GMP, GDP, and applicable regulatory requirements.
• Present in technical meetings and drive resolution of analytical-related issues.

Skills

Aseptic techniques

Analytical thinking

Attention to detail

Communication skills

Multitasking

Education

Bachelor’s or master’s degree in biology or closely related discipline

Tools

Flow cytometry

qPCR/dPCR

ELISA

HPLC

Job description

Cabaletta Bio, Inc. in Philadelphia, PA, seeks an Associate Scientist in Analytical Development to join our on-site team. You will develop, qualify, and validate analytical methods for cell therapy products, support testing at CDMOs, and drive troubleshooting across the lifecycle.

Collaboration with CMC, Quality, and external partners will be essential. The role requires a biology-based degree with 2–4 years’ experience, aseptic technique proficiency, and expertise in flow cytometry, qPCR/dPCR,