Analytical Development Scientist - Cell Therapy

Cabaletta Bio; Philadelphia (Philadelphia County); On-site; USD 75,000 - 105,000; Full time

Benefits offered by this job

Stock options

Paid time off

Job summary

Cabaletta Bio is seeking an Associate Scientist in Analytical Development on-site in Philadelphia, PA. The role focuses on method development, qualification, and analytical support for cell therapy programs, collaborating across QA, MSAT, and CDMOs to ensure compliant, high-quality assays.

The candidate will contribute to lifecycle management of analytical methods, support assay performance tracking, and assist in troubleshooting with external labs to advance preclinical and clinical programs.

Qualifications

• Bachelor’s or master’s degree in biology or a closely related field with 2–4 years of experience.
• Experience with aseptic cell culture and cell-based assays.
• Strong experience with analytical techniques (flow cytometry, qPCR/dPCR, ELISA, HPLC).
• Demonstrated experience with analytical method qualification and validation.

Responsibilities

• Develop, optimize, and qualify/validate analytical methods to evaluate safety, identity, potency of products.
• Perform analytical testing and support method development activities.
• Provide technical oversight to CDMOs and external laboratories.
• Monitor assay performance, investigate deviations and out-of-spec results.
• Collaborate with Process Development, MSAT, QA, and QC teams.
• Author/review method protocols and reports ensuring GMP/GDP compliance.
• Present in technical meetings and drive resolution of analytical issues.

Skills

Aseptic techniques

Flow cytometry

qPCR/dPCR

ELISA

HPLC

Analytical method qualification

GMP compliance

Problem solving

Communication

Education

Bachelor’s or Master’s degree in biology or closely related discipline

Job description

Cabaletta Bio is seeking an Associate Scientist in Analytical Development on-site in Philadelphia, PA. The role focuses on method development, qualification, and analytical support for cell therapy programs, collaborating across QA, MSAT, and CDMOs to ensure compliant, high-quality assays.

The candidate will contribute to lifecycle management of analytical methods, support assay performance tracking, and assist in troubleshooting with external labs to advance preclinical and clinical programs.