ALS Target Discovery Scientist – Neurology Research

IntelliPro; Cambridge (MA); On-site; USD 58,000 - 83,000; Full time

Job summary

IntelliPro is seeking a Scientist to join the Neurology Research Unit focusing on ALS. The role centers on early-stage discovery, target identification and validation using genomic and proteomic approaches in human neuron models.

You will design and execute experiments, analyze data, and contribute to publications. A PhD or Master’s in molecular biology plus hands-on experience with qPCR, ddPCR, and proteomics is preferred.

Qualifications

• Strong background in molecular biology with a focus on genomics and proteomics.
• Hands-on experience with qPCR, ddPCR, Western blotting and protein analysis techniques.
• Experience with mammalian cell culture.
• Experience with human iPSC-derived neurons or established cell lines.
• Hands-on experience with plasmid transfection and viral transduction.
• Knowledge of immunostaining, fluorescence microscopy and quantitative image analysis.
• Strong analytical, troubleshooting, and problem-solving skills.
• Ability to work independently and collaborate with research teams.
• Strong scientific documentation and data analysis skills.

Responsibilities

• Design, execute, and analyze molecular and cellular biology experiments supporting ALS target identification and validation.
• Perform molecular biology assays including qPCR, ddPCR, gel electrophoresis, and western blotting.
• Conduct proteomic studies using immunoprecipitation and quantitative platforms.
• Culture mammalian cells, transfect plasmids, and transduce with viral vectors.
• Support target validation via immunostaining and fluorescence microscopy.
• Assist with assay development, optimization, and validation.
• Generate high-quality, reproducible data and perform initial data analysis.
• Prepare data summaries, figures, and internal scientific presentations.
• Maintain accurate records and follow safety and quality standards.

Skills

Molecular biology

Genomics & proteomics

qPCR

ddPCR

Western blotting

Mammalian cell culture

iPSC-derived neurons

Viral transduction

Immunostaining

Fluorescence microscopy

Image analysis

Data analysis

Independent work

Education

PhD in Molecular Biology

Master's in Molecular Biology

Job description

IntelliPro is seeking a Scientist to join the Neurology Research Unit focusing on ALS. The role centers on early-stage discovery, target identification and validation using genomic and proteomic approaches in human neuron models.

You will design and execute experiments, analyze data, and contribute to publications. A PhD or Master’s in molecular biology plus hands-on experience with qPCR, ddPCR, and proteomics is preferred.