ALS Discovery Scientist I — Molecular & Cellular Biology

Hydrogen Group; Cambridge (MA); On-site; USD 63,000 - 70,000; Full time

Job summary

Hydrogen Group in Cambridge, MA is seeking a Scientist I to support exploratory discovery research in the ALS field. The role focuses on understanding molecular mechanisms, target identification and validation using molecular biology and cellular biology techniques in a 12-month contract.

You will perform qPCR, ddPCR, Western blots, protein analyses, and work with iPSC-derived neurons, contributing to hypothesis-driven studies and data-driven scientific decisions.

Qualifications

• Strong foundation in molecular biology, cellular biology, genomics and proteomics.
• Hands-on experience with qPCR, ddPCR, Western blotting and protein analysis.
• Proficiency in mammalian cell culture, including iPSC-derived neurons.
• Experience with plasmid transfection and viral transduction.
• Familiarity with immunoprecipitation and protein quantification assays (HTRF/AlphaLISA/MSD).
• Immunostaining, fluorescence microscopy, and quantitative image analysis.
• Ability to design experiments, troubleshoot, and optimize assays.
• Excellent documentation and data quality practices.

Responsibilities

• Execute molecular and cellular experiments to investigate disease mechanisms.
• Perform qPCR, ddPCR, gel electrophoresis, and Western blot assays.
• Conduct immunoprecipitation and protein quantification with HTRF/AlphaLISA/MSD.
• Maintain mammalian cell cultures and perform transfection/transduction in iPSC-derived neurons.
• Immunostaining and fluorescence microscopy with quantitative image analysis.
• Assist with experimental design, assay development and optimization.
• Analyze results and prepare data analyses, figures, and summaries.
• Maintain detailed lab documentation and communicate findings to the team.
• Collaborate with scientists on hypothesis-driven studies; ensure safety and data integrity.

Skills

Molecular biology

Cell biology

qPCR

ddPCR

Western blot

Mammalian cell culture

iPSC-derived neurons

Transfection

Viral transduction

Immunostaining

Fluorescence microscopy

Image analysis

Data analysis

Experimental design

Documentation

Safety procedures

Education

PhD or Master's in Molecular Biology/Neuroscience/Biochemistry

Tools

HTRF

AlphaLISA

MSD

Job description

Hydrogen Group in Cambridge, MA is seeking a Scientist I to support exploratory discovery research in the ALS field. The role focuses on understanding molecular mechanisms, target identification and validation using molecular biology and cellular biology techniques in a 12-month contract.

You will perform qPCR, ddPCR, Western blots, protein analyses, and work with iPSC-derived neurons, contributing to hypothesis-driven studies and data-driven scientific decisions.