Advanced Research Lab Specialist: AAV & Microscopy

University of Michigan; Ann Arbor (MI); Hybrid; USD 55,000 - 75,000; Full time

Benefits offered by this job

Generous time off programs

Retirement plan matching contributions

Health insurance

Tuition support

Flexible work options

Job summary

The Maurer laboratory at the University of Michigan is seeking a Research Lab Specialist Intermediate to join a team applying super-resolution microscopy, genomics, and proteomics to study vector-host interactions in rAAV gene therapies.

Ideal candidates have strong AAV biology knowledge, molecular cloning skills, and experience with mammalian cell culture. This is a full-time position based in Ann Arbor with opportunities for lab leadership and growth.

Qualifications

• Molecular biology expertise with 2+ years in AAV/vector work.
• BS/MS with 4+ years in AAV/vector research required.
• Experience in producing and QC of AAV vectors.

Responsibilities

• Develop and conduct research using microscopy and molecular biology on cultured cells and animals.
• Train and assist Fellows and students in prep, techniques, and instrument use.
• Develop assays including vector genome and titration methods.
• Maintain stocks and documentation, assist in waste disposal, promote environmentally responsible practices.
• Support administrative tasks related to research goals.

Education

Molecular and Cellular Biology-related MS degree with 2+ years of experience in Adeno-associated virus/vector research

BS or MS degree with 4+ years of experience in Adeno-associated virus/vector research (academic or industry). Experience must be with AAV, not other viral vectors.

Expertise in producing recombinant AAV vectors at small- to medium-scale, including purification, titer assessment by qPCR and ddPCR, and quality control.

Expertise in designing and implementing rAAV capsid and vector genome variants

Strong working knowledge of AAV biology and the primary literature.

Expertise in molecular cloning, including Gibson assembly, PCR, restriction digestions and ligation, site-directed mutagenesis, type II-S, and troubleshooting.

Tools

Gibson assembly

PCR

Restriction digestions

Ligation

Site-directed mutagenesis

Job description

The Maurer laboratory at the University of Michigan is seeking a Research Lab Specialist Intermediate to join a team applying super-resolution microscopy, genomics, and proteomics to study vector-host interactions in rAAV gene therapies.

Ideal candidates have strong AAV biology knowledge, molecular cloning skills, and experience with mammalian cell culture. This is a full-time position based in Ann Arbor with opportunities for lab leadership and growth.