Research Fellow (DMOAJ)

NATIONAL CANCER CENTRE OF SINGAPORE PTE LTD; Singapore; On-site; SGD 70,000 - 110,000; Full time

Job summary

The National Cancer Centre Singapore invites a motivated Research Fellow to join our translational immuno-oncology team, developing bispecific therapeutics for lung cancer. You will design, validate, and translate preclinical strategies, working with antibodies and immune-cell engagers while integrating translational development plans.

We offer access to advanced platforms, opportunities for scientific publication, collaboration with clinical teams, and a supportive environment for translational

Qualifications

• PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or closely related discipline.
• Previous research experience in cancer immunology, antibody therapeutics, T-cell biology, or lung cancer preferred.
• Strong background or interest in tumor immunology, immune evasion, T-cell activation, and antibody- or engager-based therapeutics.
• Hands-on experience with mammalian cell culture, human immune cells, and functional cell-based assays.
• Experience with multi-parameter flow cytometry and quantitative data analysis.
• Experience with tumor cytotoxicity, T-cell activation, cytokine-release, or related immune functional assays.
• Experience with mouse tumor models, in vivo imaging, recombinant proteins, antibody characterization, or bispecific/T-cell engager platforms advantageous.
• Independent, self-motivated, detail-oriented, and team-oriented, with strong scientific writing, communication, analytical, and critical-thinking skills.

Responsibilities

• Design, optimize, and execute in vitro and in vivo studies to evaluate bispecific therapeutics for lung cancer.
• Maintain and characterize lung cancer cell lines, primary tumor models and/or organoids, together with human immune cells such as PBMCs and T cells.
• Perform functional assays including tumor-cell killing, T-cell activation, proliferation, cytokine release, immune phenotyping, and 2D/3D co-culture studies.
• Conduct multi-parameter flow cytometry, live-cell imaging, and mechanism-of-action studies; analyze and interpret experimental data.
• Support relevant mouse lung cancer models, including tumor implantation, treatment, sample collection, and bioluminescence imaging where required.
• Prepare figures, reports, presentations, manuscripts, and grant-related materials; contribute to project planning and translational strategy.
• Coordinate with internal and external collaborators, guide junior research staff or students where appropriate, and support laboratory biosafety and research operations.

Skills

Immunology

Cancer biology

T‑cell biology

Mammalian cell culture

Flow cytometry

Data analysis

Education

PhD in Immunology

PhD in Cancer Biology

PhD in Biomedical Sciences

Tools

Flow cytometer

In vivo imaging

Organoid culture

Job description

We are seeking a highly motivated Research Fellow to join our translational immuno-oncologyteam developing bispecific therapeutic strategies for lung cancer. The successful candidate will contribute to the design, mechanistic evaluation, preclinical validation, and translational development of novel bispecificantibodies and immune-cell engagers.

We offer:

• Opportunity to work on an impactful translational cancer immunotherapy programme focused on next-generation bispecific therapeutics for lung cancer.
• Access to advanced platforms for flow cytometry, live-cell imaging, in vivo imaging, proteomics, and translational immune profiling.
• A multidisciplinary academic-clinical research environment with opportunities for scientific publication, collaboration, and clinical translation.

This is a full-time position.

Key Responsibilities:

• Design, optimize, and executein vitro and in vivo studies to evaluate bispecific therapeutics for lungcancer.
• Maintain and characterize lungcancer cell lines, primary tumor models and/or organoids, together with humanimmune cells such as PBMCs and T cells.
• Perform functional assaysincluding tumor-cell killing, T-cell activation, proliferation, cytokinerelease, immune phenotyping, and 2D/3D co-culture studies.
• Conduct multi-parameter flowcytometry, live-cell imaging, and mechanism-of-action studies; analyze andinterpret experimental data.
• Support relevant mouse lungcancer models, including tumor implantation, treatment, sample collection, andbioluminescence imaging where required.
• Prepare figures, reports,presentations, manuscripts, and grant-related materials; contribute to projectplanning and translational strategy.
• Coordinate with internal andexternal collaborators, guide junior research staff or students whereappropriate, and support laboratory biosafety and research operations.

Key Requirements:

• PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or a closely related discipline.
• Previous research experience in cancer immunology, antibody therapeutics, T-cell biology, or lung cancer is preferred.
• Strong background or interest in tumor immunology, immune evasion, T-cell activation, and antibody- or engager-based cancer therapeutics.
• Hands-on experience with mammalian cell culture, human immune cells, and functional cell-based assays.
• Experience with multi-parameter flow cytometry and quantitative data analysis.
• Experience with tumor cytotoxicity, T-cell activation, cytokine-release, or related immune functional assays.
• Experience with mouse tumor models, in vivo imaging, recombinant proteins, antibody characterization, or bispecific/T-cell engager platforms is advantageous.
• Independent, self-motivated, detail-oriented, and team-oriented, with strong scientific writing, communication, analytical, and critical-thinking skills.