Research Fellow (DMOAJ)

SingHealth Group; Singapore; On-site; SGD 60,000 - 100,000; Full time

Benefits offered by this job

Impactful translational cancer immuno-

Access to advanced flow cytometry & in

Multidisciplinary academic-clinical环境

Job summary

National Cancer Centre Singapore Pte Ltd is seeking a highly motivated Research Fellow to contribute to the design, mechanistic evaluation, preclinical validation, and translational development of novel bispecific antibodies and immune-cell engagers for lung cancer.

The role involves leading in vitro and in vivo studies, maintaining lung cancer cell lines and primary tumor models, and collaborating with cross-disciplinary teams to advance translational cancer immunotherapy projects.

Qualifications

• PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or related field.

Responsibilities

• Design, optimize, and execute in vitro and in vivo studies to evaluate bispecific therapeutics for lung cancer.

Skills

Cancer Immunology

T-cell Biology

Antibody Therapeutics

In Vivo Tumor Models

Immune Profiling

Mammalian Cell Culture

Flow Cytometry

Education

PhD in Immunology or Cancer Biology

Job description

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National Cancer Centre of Singapore Pte Ltd

Research Fellow (DMOAJ)

Job Category: Research

Posting Date: 12 Oct 2026

We are seeking a highly motivated Research Fellow to join our translational immuno-oncologyteam developing bispecific therapeutic strategies for lung cancer. The successful candidate will contribute to the design, mechanistic evaluation, preclinical validation, and translational development of novel bispecificantibodies and immune-cell engagers.

We offer:

• The opportunity to work on an impactful translational cancer immunotherapy programme focused on next-generation bispecific therapeutics for lung cancer.
• Access to advanced platforms for flow cytometry, live-cell imaging, in vivo imaging, proteomics, and translational immune profiling.
• A multidisciplinary academic-clinical research environment with opportunities for scientific publication, collaboration, and clinical translation.
• This is a full-time position.
• Candidates with strong hands-on experience in cancer immunology, functional T-cell assays, bispecific/antibody therapeutics, or relevant in vivo tumor models.

Key Responsibilities:

• Design, optimize, and executein vitro and in vivo studies to evaluate bispecific therapeutics for lungcancer.
• Maintain and characterize lungcancer cell lines, primary tumor models and/or organoids, together with humanimmune cells such as PBMCs and T cells.
• Perform functional assaysincluding tumor-cell killing, T-cell activation, proliferation, cytokine-release, immune phenotyping, and 2D/3D co-culture studies.
• Conduct multi-parameter flowcytometry, live-cell imaging, and mechanism-of-action studies; analyze andinterpret experimental data.
• Support relevant mouse lungcancer models, including tumor implantation, treatment, sample collection, andbioluminescence imaging where required.
• Prepare figures, reports,presentations, manuscripts, and grant-related materials; contribute to projectplanning and translational strategy.
• Coordinate with internal andexternal collaborators, guide junior research staff or students whereappropriate, and support laboratory biosafety and research operations.

Key Requirements:

• PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or a closely related discipline.
• Previous research experience in cancer immunology, antibody therapeutics, T-cell biology, or lung cancer is preferred.
• Strong background or interest in tumor immunology, immune evasion, T-cell activation, and antibody- or engager-based cancer therapeutics.
• Hands-on experience with mammalian cell culture, human immune cells, and functional cell-based assays.
• Experience with multi-parameter flow cytometry and quantitative data analysis.
• Experience with tumor cytotoxicity, T-cell activation, cytokine-release, or related immune functional assays.
• Experience with mouse tumor models, in vivo imaging, recombinant proteins, antibody characterization, or bispecific/T-cell engager platforms is advantageous.
• Independent, self-motivated, detail-oriented, and team-oriented, with strong scientific writing, communication, analytical, and critical-thinking skills.