Preclinical Leader - Cardiometabolic RNA Therapeutics

A*STAR Research; Singapore; On-site; SGD 90,000 - 150,000; Full time

Benefits offered by this job

Attractive benefits

Long-term career growth opportunities

Competitive compensation package

Job summary

A*STAR - Agency for Science, Technology and Research in Singapore is seeking a Preclinical Programme Leader for Cardiovascular & Metabolic Diseases. This role drives discovery and clinical development of oligonucleotide programmes, managing projects from target validation to preclinical candidates. Ideal candidates will have a PhD and significant experience in siRNA/ASO discovery, along with strong skills in managing in vivo studies and collaboration. A highly competitive compensation package is offered in Singapore's biomedical innovation ecosystem.

Qualifications

• Minimum 4+ years for Scientist, 8+ for Senior Scientist, 12+ for Principal Scientist.
• Strong hands-on expertise in cell-based screening and mechanistic assays.
• Experience with obesity and MASH disease models.

Responsibilities

• Drive discovery toward clinical development of oligonucleotide programmes.
• Establish integrated workflows to support pipeline projects.
• Design and optimise in vitro screening cascades.

Skills

siRNA/ASO discovery

In vivo PK/PD studies

Drug discovery

Project management

Collaboration

Education

PhD in Molecular Biology or related discipline

Job description

A*STAR - Agency for Science, Technology and Research in Singapore is seeking a Preclinical Programme Leader for Cardiovascular & Metabolic Diseases. This role drives discovery and clinical development of oligonucleotide programmes, managing projects from target validation to preclinical candidates. Ideal candidates will have a PhD and significant experience in siRNA/ASO discovery, along with strong skills in managing in vivo studies and collaboration. A highly competitive compensation package is offered in Singapore's biomedical innovation ecosystem.