Senior Scientist, Target Discovery for RNA Therapeutics

A*STAR Research; Singapore; On-site; SGD 150,000 - 210,000; Full time

Job summary

Nucleic Acid Therapeutics Initiative (NATi), hosted by A*STAR in Singapore, seeks an experienced Scientist/Senior Scientist in Target Discovery & Validation. Lead discovery, integrate human genetics, and drive RNA modality targets for MASH, obesity, and metabolic diseases.

Translate computational outputs into actionable hypotheses with cross-functional leadership. The role emphasizes translational biology, data-driven decision making, and collaboration across bioinformatics, biology, and

Qualifications

• PhD in Biology, Genetics, Genomics, Bioinformatics, Pharmacology, or related discipline.
• 5+ years (Scientist) or 10+ years (Sr. Scientist) in target discovery, human genetics, or translational disease biology.
• Proficiency in Python or R for data analysis and visualization.
• Experience interpreting multi-omic data and collaborating with bioinformaticians.

Responsibilities

• Lead target discovery portfolio for RNA therapeutics in metabolic diseases.
• Translate human genetics and multi-omics data into testable hypotheses and targets.
• Establish a standardized computational target ranking framework for go/no-go decisions.
• Bridge bioinformatics, biology, and pharmacology teams to advance targets.

Skills

Python

R

Multi-omics

Genetics

Communication

Education

PhD in Biology/Genomics/Bioinformatics/Pharmacology

Job description

Nucleic Acid Therapeutics Initiative (NATi), hosted by A*STAR in Singapore, seeks an experienced Scientist/Senior Scientist in Target Discovery & Validation. Lead discovery, integrate human genetics, and drive RNA modality targets for MASH, obesity, and metabolic diseases.

Translate computational outputs into actionable hypotheses with cross-functional leadership. The role emphasizes translational biology, data-driven decision making, and collaboration across bioinformatics, biology, and