Lead, Preclinical Cardiometabolic RNA Therapeutics

A*STAR Research; Singapore; On-site; SGD 100,000 - 150,000; Full time

Benefits offered by this job

Attractive benefits

Long-term career growth opportunities

Job summary

A leading biomedical research institute in Singapore is seeking a Preclinical Programme Leader for Cardiovascular & Metabolic Diseases. This role will encompass overseeing siRNA and ASO development from target validation to candidate selection for clinical studies. The ideal candidate will have extensive experience in RNA therapeutics, strong hands-on laboratory skills, and a PhD in Molecular Biology or a related field. The position offers competitive compensation and opportunities for growth within Singapore's thriving biomedical ecosystem.

Qualifications

• Minimum of 4+ years (Scientist), 8+ (Senior Scientist) or 12+ (Principal Scientist) years of experience leading siRNA/ASO discovery programmes.
• Strong expertise in obesity and MASH disease models.
• Experience in early drug discovery from target validation to lead generation.

Responsibilities

• Own end-to-end scientific and project strategy for siRNA/ASO discovery programmes.
• Establish integrated workflows to support pipeline projects.
• Design and oversee in vivo PK/PD studies.

Skills

Hands-on laboratory expertise

Programme management skills

Collaborative mentoring

Data-driven leadership

Education

PhD in Molecular Biology, Pharmacology, Biochemistry or related discipline

Tools

In vivo PK/PD models

Cell-based assays

Job description

A leading biomedical research institute in Singapore is seeking a Preclinical Programme Leader for Cardiovascular & Metabolic Diseases. This role will encompass overseeing siRNA and ASO development from target validation to candidate selection for clinical studies. The ideal candidate will have extensive experience in RNA therapeutics, strong hands-on laboratory skills, and a PhD in Molecular Biology or a related field. The position offers competitive compensation and opportunities for growth within Singapore's thriving biomedical ecosystem.