Independent Scientist, 3D Skin & Neurovascular Models

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 140,000 - 190,000; Full time

Job summary

A*STAR invites applications for a highly motivated scientist to join an interdisciplinary lab focused on organotypic skin models and neurovascular unit systems using 3D microphysiological platforms. The ideal candidate will bring expertise in skin biology or neuroscience and will expand into the complementary discipline.

The role emphasizes 3D tissue engineering, advanced imaging, and multi-omics, with opportunities to mentor juniors and publish in top journals.

Qualifications

• PhD in Biomedical Engineering, Biotechnology, Biological Science or related disciplines.
• Strong track record of productivity with first-author publications in top journals.
• Deep expertise in either skin biology or neuroscience with a solid foundation in cellular/molecular mechanisms of inflammation and tissue dysfunction.
• Experience with 3D organ-on-a-chip models, stem cell biology/differentiation and gene editing; hands-on with vascularized/immune-competent tissue models, including skin and/or NVU models.
• Proficiency in advanced imaging techniques (confocal microscopy, image analysis) and molecular biology methods.
• Experience in single-cell RNA-seq data analysis and data interpretation for figures in publications.
• Demonstrated ability to work independently, design/execute complex experiments, manage multiple projects, and meet deadlines.
• Flexible, proactive problem-solver with strong collaboration and communication skills.

Responsibilities

• Design and execute experiments for 3D organotypic model development, including hiPSC culture/differentiation.
• Integrate epithelial, stromal, endothelial, immune and neural components into MPSs.
• Perform advanced tissue characterization using histology, immunostaining, fluorescence, confocal microscopy, flow cytometry, qPCR and multi-omics.
• Analyze data, prepare high-quality figures, contribute to manuscript writing and present at lab meetings.
• Stay current with literature, supervise junior researchers, ensure rigorous data management, safety, and lab organization.

Skills

Skin biology or Neuroscience expertise

3D organ-on-a-chip models

hiPSC culture & differentiation

Gene editing

Vascularized/immune-competent tissue

Imaging analysis

Single-cell RNA-seq data analysis

Independent project management

Cross-disciplinary collaboration

Scientific communication

Education

PhD in Biomedical Engineering, Biotechnology or Biological Science

Tools

Confocal microscopy

Flow cytometry

Histology

Molecular biology techniques

Image analysis

Job description

A*STAR invites applications for a highly motivated scientist to join an interdisciplinary lab focused on organotypic skin models and neurovascular unit systems using 3D microphysiological platforms. The ideal candidate will bring expertise in skin biology or neuroscience and will expand into the complementary discipline.

The role emphasizes 3D tissue engineering, advanced imaging, and multi-omics, with opportunities to mentor juniors and publish in top journals.