Scientist, A*STAR Skin Research Labs

A*STAR Research Entities (A*STAR); Singapore; On-site; SGD 90,000 - 150,000; Full time

Job summary

A*STAR Research Entities (A*STAR) in Singapore is seeking a highly motivated scientist to drive interdisciplinary 3D organotypic model development for skin and neurovascular unit systems. You will integrate multiple cell types into microphysiological systems and apply advanced imaging and multi-omics to understand inflammation and aging processes.

Applicants should have a PhD and an established publication record, with deep expertise in skin biology or neuroscience and hands-on experience in

Qualifications

• PhD required in Biomedical Engineering, Biotechnology, Biological Science or related field.
• First-author publications in top journals are expected.
• Deep expertise in skin biology or neuroscience with a strong understanding of inflammation and tissue dysfunction.
• Hands-on experience with organ-on-a-chip, stem cell differentiation and gene editing; vascularized/immune-competent tissue models preferred.
• Proficiency in advanced imaging, histology, molecular biology techniques and data interpretation.

Responsibilities

• Design and execute experiments for 3D organotypic model development (hiPSC culture and differentiation).
• Integrate epithelial, stromal, endothelial, immune and neural components into MPSs.
• Characterize tissues using histology, immunostaining, confocal microscopy, flow cytometry, qPCR and multi-omics.
• Present data in lab meetings and contribute to manuscript writing.
• Maintain rigorous documentation, data management, safety compliance and overall lab organization.

Skills

Skin biology or neuroscience

Advanced imaging (confocal)

Single-cell RNA-seq analysis

Independent project execution

Communication and collaboration

Education

PhD in Biomedical Engineering or related

Tools

Organ-on-a-chip

Stem cell differentiation

Gene editing

3D tissue modeling

Job description

Job Summary

We are looking for a highly motivated, resourceful, and independent scientist to join our interdisciplinary lab, contributing to projects spanning organotypic skin models and neurovascular unit (NVU) models. Candidates with deep expertise in either skin biology or neuroscience are encouraged to apply, with the opportunity to broaden their expertise into the other discipline. The work will focus on mechanisms of skin health, aging and inflammation, and on neurovascular development and dysfunction, using advanced 3D microphysiological systems (MPSs).

Please reach out to Giulia (***email_hidden***) if you are interested in this position.

Roles and Responsibilities

The candidate will design and execute experiments for 3D organotypic model development, including hiPSC culture and differentiation, integration of epithelial, stromal, endothelial, immune and neural components into MPSs, and gene-editing approaches. The role involves advanced tissue characterization using histology, immunostaining, fluorescence and confocal microscopy, flow cytometry, qPCR and multi-omics, as well as independent data analysis and interpretation, presentation in lab meetings, preparation of high-quality figures and contribution to manuscript writing. The candidate is expected to stay up to date with advances in the field, maintain a strong knowledge of relevant literature, contribute to collaborative projects, supervise junior researchers and ensure rigorous documentation, data management, safety compliance and overall laboratory organization.

Requirements

• PhD in Biomedical Engineering, Biotechnology, Biological Science or related disciplines
• Strong track record of productivity, including first-author publications in top-cited journals
• Deep expertise in either skin biology or neuroscience, with a strong foundation in cellular/molecular mechanisms relevant to inflammation and tissue dysfunction
• Expertise in 3D organ-on-a-chip models, stem cell biology/differentiation and gene editing; hands-on experience with vascularized and/or immune-competent tissue models, ideally including skin organotypic systems and/or neurovascular unit models
• Proficiency in advanced imaging techniques, including confocal microscopy and image analysis, histology and molecular biology techniques
• Experience in single-cell RNA-seq data analysis, including data interpretation and figure preparation for scientific publications
• Demonstrated ability to work independently - designing and executing complex experimental protocols, managing multiple projects, and delivering on schedule in a fast-paced environment
• Flexible, fast-learning mindset with resourceful problem-solving skills, comfortable adapting across disciplines and troubleshooting roadblocks with a positive, proactive attitude
• Excellent communication and interpersonal skills, with attention to detail and commitment to scientific rigor