Principal Clinical Scientist

Alignerr; Portugal; Remote; EUR 83,000 - 179,000; Part time

Job summary

Alignerr is seeking a Principal Clinical Scientist (AI Training) for a remote hourly contract. You will craft and review regulatory-grade trial protocols used to generate regulator-ready datasets for AI training, and audit results to ensure accuracy and regulatory alignment.

The role emphasizes high scientific rigor and self-direction on a flexible schedule. Ideal candidates have senior trial design experience, biostatistics knowledge, and familiarity with regulatory submissions to agencies like

Qualifications

• Senior professional with trial design for regulatory submission.
• Experience interpreting data for agencies such as FDA/EMA.
• Strong background in clinical research methodology.

Responsibilities

• Design and review regulatory-grade trial protocols for AI training.
• Audit clinical trial results for accuracy and regulatory alignment.
• Evaluate AI-generated analyses for regulatory relevance.
• Provide expert feedback to improve AI model reasoning on trial data.
• Establish scientific credibility of AI outputs in clinical contexts.

Skills

Senior-level

Regulatory submission

Biostatistics expertise

Clinical trial design

Education

Regulatory science experience

Job description

Principal Clinical Scientist (AI Training)

What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence for millions of patients worldwide? We're looking for a Principal Clinical Scientist to bring senior-level rigor to cutting-edge AI research workflows. In this role, your deep knowledge of regulatory-grade clinical data will help ensure that the AI systems influencing biomedical research are built on a foundation of scientific integrity — the kind that holds up to real-world scrutiny. This is a fully remote, flexible contract role designed for experienced clinical scientists who want meaningful, high-impact work on their own schedule.

About The Role

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Provide expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Help establish the scientific credibility of AI outputs in clinical and biomedical contexts

Who You Are

• Senior-level professional with hands-on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies
• Strong background in clinical research methodology, biostatistics, or translational science
• Naturally rigorous — you hold AI-generated content to the same standards you'd apply in a real submission
• Self-directed and comfortable delivering high-quality work independently

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI training workflows
• Familiarity with AI tools or clinical NLP systems as an end user
• Experience spanning multiple therapeutic areas or regulatory jurisdictions
• Background in academic clinical research, CRO environments, or regulatory consulting

Why Join Us

• Work directly on frontier AI systems that are reshaping clinical and biomedical research
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level work
• Influence how AI understands, evaluates, and communicates real-world clinical evidence at scale
• Potential for ongoing work and contract extension as new projects launch