PhD: Shape Next-Gen Retina Cell Therapies from Patient Models

AcademicTransfer; Netherlands; On-site; EUR 36,000 - 45,000; Full time

Benefits offered by this job

BeFrank pension

Public transport reimbursement

Bike scheme

End-of-year bonus (8.3%)

Job summary

Amsterdam UMC Research BV, in collaboration with the Lifelong VISION program, is seeking a First Stage Researcher (R1) to develop and characterize patient-based preclinical models for inherited retinal diseases. You will work with patient-derived stem cells, differentiate protocols for retinal cell models, and explore in vivo constructs to evaluate cell therapy approaches.

This four-year PhD connects model systems and cell-based therapy within Emma CPM.

Qualifications

• Master's degree completed in a biomedical field.
• Experience in experimental lab research and cell culture; stem cells/differentiation is an advantage.
• Interest in disease models and in the relation between genetic variation, cellular function and clinical characteristics.
• Willingness to work with in vivo models and to undertake required training; Article 9 qualification is an advantage.
• Good communication skills in English; proficiency in Dutch is an advantage.

Responsibilities

• Develop, characterize and apply patient-based preclinical models.
• Work with patient-derived stem cells and optimize differentiation protocols for retinal cell/tissue models.
• Characterize new in vitro models at molecular, cellular and functional levels and reflect disease characteristics.
• Develop and characterize patient-based in vivo models and establish outcome measures for disease progression and treatment.
• Integrate experimental findings with genetic and clinical patient data in collaboration with researchers and clinicians.
• Present results within Lifelong VISION, Emma CPM and at scientific meetings and contribute to publications and PhD thesis.

Skills

Communication skills

English proficiency

Dutch advantage

Education

Master's degree in biomedical sciences / related field

Job description

Amsterdam UMC Research BV, in collaboration with the Lifelong VISION program, is seeking a First Stage Researcher (R1) to develop and characterize patient-based preclinical models for inherited retinal diseases. You will work with patient-derived stem cells, differentiate protocols for retinal cell models, and explore in vivo constructs to evaluate cell therapy approaches.

This four-year PhD connects model systems and cell-based therapy within Emma CPM.