PhD Candidate: Brain Barrier Drug Delivery & Organoids

Amsterdam UMC; Amsterdam; On-site; EUR 36,000 - 45,000; Full time

Benefits offered by this job

End-of-year bonus 8.3%

Public transport reimbursement

Bike scheme

Pension BeFrank

Job summary

Amsterdam UMC in Amsterdam invites applications for a researcher to develop and apply advanced human in vitro models to study drug delivery across the blood-brain barrier. You will compare nanocarriers, work with hiPSC-derived organoids and BBB models, and investigate neurovascular interactions to aid disease modelling and drug screening.

You will collaborate with researchers from Amsterdam UMC and Locsense within an interdisciplinary public-private partnership, contributing to disease modelling

Qualifications

• Master’s degree in neuroscience, biomedical sciences or a related field.
• Interest in in vitro modelling, nanoparticle technologies, blood-brain barrier biology and neurodegenerative diseases.
• Experience with hiPSC culture and differentiation and/or in vitro blood-brain barrier models and brain organoids.
• Experience with organ-on-chip, MEA or nanoparticle technologies is an advantage.
• Excellent written and verbal communication skills in English, proactive and flexible attitude, and the ability to work independently as well as collaboratively.

Responsibilities

• Develop and apply advanced human in vitro models to study drug delivery across the blood-brain barrier.
• Compare therapeutic potential of natural and synthetic nanocarriers.
• Work with hiPSC-derived cortical brain organoids and human blood-brain barrier models.
• Investigate neurovascular interactions and brain delivery of therapeutic compounds.
• Collaborate with researchers from Amsterdam UMC and Locsense within this interdisciplinary partnership.

Skills

hiPSC culture

brain organoids

in vitro modelling

nanoparticle tech

English fluency

Education

Master’s degree in neuroscience, biomedical sciences or related field

Tools

organ-on-chip

MEA

Job description

Amsterdam UMC in Amsterdam invites applications for a researcher to develop and apply advanced human in vitro models to study drug delivery across the blood-brain barrier. You will compare nanocarriers, work with hiPSC-derived organoids and BBB models, and investigate neurovascular interactions to aid disease modelling and drug screening.

You will collaborate with researchers from Amsterdam UMC and Locsense within an interdisciplinary public-private partnership, contributing to disease modelling