Jr. Scientist in vitro disease biology

VectorY Therapeutics; Amsterdam; Hybrid; EUR 42,000 - 64,000; Full time

Benefits offered by this job

Salary package

30 holiday days

Development opportunities

Job summary

VectorY Therapeutics in Amsterdam Science Park is seeking a highly motivated Junior Scientist for the Discovery team. In this hands-on role you will develop and perform in vitro screening and validation assays using neuronal models to advance therapeutic discovery programs.

You will work on neuronal cell culture, imaging-based assays and molecular biology techniques, collaborating with experts across neuroscience, cell biology, and AAV biology.

Qualifications

• PhD in Neuroscience, Molecular Biology, or related field.
• Experience with aseptic neuronal cell culture.
• Fluency in written and spoken English.
• Experience with human iPSC-derived neuronal cultures preferred.
• Strong understanding of CNS biology and disease mechanisms.

Responsibilities

• Coordinate research projects to develop in vitro models of neurodegenerative disorders.
• Design and execute experiments for disease-relevant cellular models.
• Collaborate with cross-functional teams across VectorY departments.
• Document work in study plans and reports.
• Analyze and present experimental data clearly.
• Maintain collaborations with CROs or academic partners.

Skills

Neuroscience

Molecular biology

Cell culture

Fluorescence microscopy

Data analysis

Project leadership

Collaboration

English communication

Education

PhD in Neuroscience or related field

Tools

Fluorescence microscopy

Cell-based assays

Imaging-based assays

Job description

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the therapeutic potential of antibodies combined with AAV based delivery to develop long-lasting therapeutic solutions for neurodegenerative diseases of high unmet medical need.

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated precision medicines company focused on the development of innovative vectorized antibody therapies for the treatment of neurodegenerative diseases such as ALS, Huntington's disease, and Alzheimer's disease.

Short description of the Discovery department

The Research Department forms the foundation of the VectorY proprietary and partnered programs and, together with the Vector Development department, works towards the development of vectorized antibody treatments for neurodegenerative diseases. We develop and test new therapeutic candidates in different in vitro and in vivo pre-clinical settings and models, to select and advance the therapeutic candidate towards the clinical translation.

We are seeking a highly motivated Junior Scientist to join our Discovery team. In this hands-on laboratory role, you will develop and perform in vitro screening and validation assays using disease-relevant models to advance therapeutic discovery programs. Your work will focus on neuronal cell culture, phenotypic screening, imaging-based assays, and molecular biology techniques, in collaboration with experts across neuroscience, cell biology, molecular and AAV biology, and drug discovery.

Main responsibilities:

• Manage and coordinate, in collaboration with other scientists, research projects to develop in vitro models of neurodegenerative disorders and test therapeutic candidates.
• Own, design and execute experiments, in collaboration with technicians, for the development and optimization of disease-relevant cellular models.
• Work in cross-functional teams, collaborating with other scientists within the different VectorY's departments.
• Document the work in study plans and reports.
• Analyze, interpret, and present experimental data in a clear and scientifically rigorous manner.
• Maintain communication and collaborations with third parties, such as CROs or academic institutions.

Skills and Qualifications:

• PhD in Neuroscience, Molecular Biology, or a related discipline.
• Strong understanding of CNS biology, molecular biology, and disease mechanisms, expertise in neurodegenerative disorders such as ALS and FTD is a big plus.
• Extensive experience with aseptic neuronal cell culture techniques.
• Experience with human iPSC-derived neuronal cultures is preferred.
• Expertise in fluorescence microscopy and cell-based assays, combined with strong analytical skills.
• Demonstrated ability to design, lead, and execute research projects effectively.
• Ability to work independently, with strong problem-solving skills.
• Strong collaborative mindset and ability to work productively in a fast-paced, multidisciplinary environment.
• Fluency in written and spoken English.

Your Natural Strengths and Drivers

You are scientifically driven, thorough, and have the ability to manage research projects and set priorities. We look for a team player with a get-things-done mentality. You work consistently in a fast-paced environment, taking ownership and managing priorities.

Working at VectorY

Challenging and varied work with a real impact. We offer an attractive salary package, 30 holiday days and every opportunity to develop yourself. An authentic experience within a young, ambitious biotech company on the path to bring innovative therapies to patients worldwide.