Clinical Trial Manager

Sire Search; Utrecht; On-site; EUR 70,000 - 100,000; Full time

Job summary

Sire Search is seeking a Clinical Trial Manager to own the operational delivery of clinical trials, lead a cross‑functional trial team, and manage CRO partnerships in a highly regulated life sciences environment.

You will drive trial delivery on time and within budget, oversee budgets, forecasting, accruals and invoicing, monitor CRO performance, and escalate risks to protect progress and data integrity. Strong ICH‑GCP knowledge and SOP adherence are essential.

Qualifications

• Bachelor’s degree in a relevant field; Master’s degree preferred.
• 5+ years of experience in Clinical Operations.
• Proven experience leading and managing clinical trials.
• Strong experience working with CROs and coordinating trial activities.
• Solid understanding of regulated clinical trial delivery and quality expectations (ICH-GCP and SOPs).
• Comfortable working with trial documentation and budget monitoring.

Responsibilities

• Lead the trial-specific cross-functional Clinical Management Team, including oversight of CRO partners.
• Drive trial delivery to meet agreed timelines, budget, and quality expectations.
• Build strong collaboration with internal and external stakeholders to support smooth trial progress.
• Support selection of CROs and contribute to defining scope of work and expectations.
• Actively manage CRO performance and ensure clear communication and follow-up.
• Identify and escalate issues/risks to protect progress and quality.
• Support audits and inspections and drive timely responses.
• Maintain and manage trial budgets, including forecasting, accruals, and invoicing.
• Lead risk management activities related to patient safety and data integrity.

Skills

Leadership

Trial management

CRO coordination

ICH-GCPs

Education

Bachelor's degree

Master’s degree preferred

Job description

Company

Our client is a leading organisation in the life sciences sector, focused on developing innovative therapies and running high-quality clinical research. The team works in a highly regulated environment and partners closely with internal stakeholders and external vendors to deliver trials efficiently, safely, and in full compliance.

Job Description

We are looking for a Clinical Trial Managerto take ownership of the operational delivery of clinical trials. This person will lead a cross-functional trial team, manage external partners such as CROs, and ensure trials are delivered on time, within budget, and to the required quality and compliance standards.

Responsibilities

• Lead the trial-specific cross-functional Clinical Management Team, including oversight of CRO partners.
• Drive trial delivery to meet agreed timelines, budget, and quality expectations.
• Build strong collaboration with internal and external stakeholders to support smooth trial progress.
• Support selection of CROs and contribute to defining scope of work and expectations.
• Actively manage CRO performance throughout the trial and ensure clear communication and follow-up.
• Ensure issues and risks are identified early and escalated appropriately to protect progress and quality.
• Support audits and inspections and help drive timely responses when needed.
• Maintain and manage trial budgets, including forecasting, accruals, and invoice coordination.
• Lead risk management activities related to patient safety and data integrity.

Requirements

• Bachelor’s degree in a relevant field (Master’s degree preferred).
• At least 5+ years of experience in Clinical Operations.
• Proven experience leading and managing clinical trials.
• Strong experience working with CROs and coordinating trial activities.
• Solid understanding of regulated clinical trial delivery and quality expectations (e.g., ICH-GCP and internal SOPs).
• Comfortable working with trial documentation and budget monitoring.
• Temporary Full-Time Contract (6 Months)

Other Information

This is a great opportunity for an experienced clinical operations professional who enjoys owning trial delivery and working closely with a wide range of stakeholders.